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Details on Person SNX9 recruits components of the actin polymerizing machinery

Class:Id	Reaction:8868230
_displayName	SNX9 recruits components of the actin polymerizing machinery
_doRelease	TRUE
_timestamp	2016-05-19 16:46:07
authored	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8868233] Rothfels, Karen, 2016-04-19
edited	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
input	[Complex:8867751] PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] [Homo sapiens] [Polymer:202986] f-actin [plasma membrane] [Homo sapiens] [Complex:8868219] HIP1 dimer [cytosol] [Homo sapiens] [Complex:8868221] HIP1R dimer [cytosol] [Homo sapiens] [DefinedSet:8868228] WASL,CTTN [cytosol] [Homo sapiens] [Complex:8868713] ARP2/3 complex [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8871069] Actin dynamics counteract membrane tension during clathrin-mediated endocytosis [LiteratureReference:8868162] A high precision survey of the molecular dynamics of mammalian clathrin-mediated endocytosis [LiteratureReference:8868161] A feedback loop between dynamin and actin recruitment during clathrin-mediated endocytosis [LiteratureReference:8856473] Molecular mechanism and physiological functions of clathrin-mediated endocytosis [LiteratureReference:8868198] SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis [LiteratureReference:8868202] Sorting nexin 9 interacts with dynamin 1 and N-WASP and coordinates synaptic vesicle endocytosis [LiteratureReference:8868004] SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2 [LiteratureReference:8868183] Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits [LiteratureReference:8868197] SNX9 - a prelude to vesicle release [LiteratureReference:8868207] The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis [LiteratureReference:8868171] Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins [LiteratureReference:8868193] HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2 [LiteratureReference:8868189] HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain [LiteratureReference:8868168] Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain
modified	[InstanceEdit:8868714] Rothfels, Karen, 2016-04-22 [InstanceEdit:8870656] Rothfels, Karen, 2016-05-10 [InstanceEdit:8870663] Rothfels, Karen, 2016-05-10 [InstanceEdit:8871208] Rothfels, Karen, 2016-05-13 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SNX9 recruits components of the actin polymerizing machinery
output	[Complex:8868232] PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:8867754] F- and N- BAR domain proteins bind the clathrin-coated pit [Homo sapiens] [Reaction:8868071] Clathrin recruits PIK3C2A [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:8870617] Antonescu, Costin N, 2016-05-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873352] R-HSA-8868230.3
summation	[Summation:8868231] Actin polymerization is not absolutely required for clathrin...
(hasEvent)	[Pathway:8856828] Clathrin-mediated endocytosis [Homo sapiens]
(precedingEvent)	[Reaction:8868236] BAR domain proteins recruit dynamin [Homo sapiens]
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No pathways have been reviewed or authored by SNX9 recruits components of the actin polymerizing machinery (8868230)