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Details on Person MAPK12 phosphorylates PTPN3

Class:IdReaction:8868118
_displayNameMAPK12 phosphorylates PTPN3
_doReleaseTRUE
_timestamp2020-05-04 20:38:16
authored[InstanceEdit:8868081] Rothfels, Karen, 2016-04-18
catalystActivity[CatalystActivity:8868115] protein serine/threonine kinase activity of PTPN3:p-T183,Y185-MAPK12 [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:8868119] Rothfels, Karen, 2016-04-19
edited[InstanceEdit:8868081] Rothfels, Karen, 2016-04-18
input[Complex:8867651] PTPN3:p-T183,Y185-MAPK12 [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:8868108] p38γ Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response
[LiteratureReference:8867632] PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction
[LiteratureReference:8867629] Essential role of p38gamma in K-Ras transformation independent of phosphorylation
[LiteratureReference:8867646] Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain-modulated complex formation
modified[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9674640] Rothfels, Karen, 2020-01-17
[InstanceEdit:9676028] Rothfels, Karen, 2020-02-06
[InstanceEdit:9676768] Rothfels, Karen, 2020-02-20
[InstanceEdit:9686661] Rothfels, Karen, 2020-05-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameMAPK12 phosphorylates PTPN3
output[Complex:8868113] p-S459 PTPN3:p-T183,Y185-MAPK12 [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
releaseDate2020-03-17
reviewed[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8904354] R-HSA-8868118.2
summation[Summation:8868117] PTPN3 has been shown to bind to phosphorylated MAPK12 and pr...
(hasEvent)[Pathway:5675221] Negative regulation of MAPK pathway [Homo sapiens]
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