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Details on Person PTPN3 has been shown to bind to phosphorylated MAPK12 and pr...
| Class:Id | Summation:8868117 |
|---|---|
| _displayName | PTPN3 has been shown to bind to phosphorylated MAPK12 and pr... |
| _timestamp | 2020-05-04 20:38:33 |
| created | [InstanceEdit:8868116] Rothfels, Karen, 2016-04-19 |
| modified | [InstanceEdit:9686661] Rothfels, Karen, 2020-05-04 |
| text | PTPN3 has been shown to bind to phosphorylated MAPK12 and promote its dephosphorylation, and this interaction is correlated with increased oncogenic signaling through RAS (Hou et al, 2010; Tang et al, 2005; Chen et al, 2014 ). Although the mechanism for this PTPN3 and MAPK12-dependent activation of RAS signaling is not known, dephosphorylation of MAPK12 allows the recovery of larger amounts of MAPK12 from a complex with ERK proteins, suggesting a possible mechanism. A more recent study, however, has found that PTPN3 is itself phosphorylated in a MAPK12-dependent fashion upon binding with phospho-MAPK12. This phosphorylation antagonizes SOB-induced growth inhibition and increases RAS-dependent oncogenic growth (Hou et al, 2012). |
| (summation) | [Reaction:8868118] MAPK12 phosphorylates PTPN3 [Homo sapiens] |
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