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Details on Person Clathrin recruits PIK3C2A

Class:Id	Reaction:8868071
_displayName	Clathrin recruits PIK3C2A
_doRelease	TRUE
_timestamp	2016-05-19 16:46:07
authored	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8868070] Rothfels, Karen, 2016-04-18
edited	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
input	[EntityWithAccessionedSequence:1604624] PIK3C2A [cytosol] [Homo sapiens] [Complex:8867753] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1675792] The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles [LiteratureReference:8868029] The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking [LiteratureReference:8867995] Individual phosphoinositide 3-kinase C2alpha domain activities independently regulate clathrin function [LiteratureReference:8868016] Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate [LiteratureReference:8867983] BAR domain scaffolds in dynamin-mediated membrane fission
modified	[InstanceEdit:8870634] Rothfels, Karen, 2016-05-10 [InstanceEdit:8870663] Rothfels, Karen, 2016-05-10 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Clathrin recruits PIK3C2A
output	[Complex:8868051] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit [Homo sapiens] [Reaction:8863718] AGFG1 binds VAMP7 [Homo sapiens] [Reaction:8866277] AP-2 directly binds some endocytic cargo [Homo sapiens] [Reaction:8866283] ARBB recruits GPCRs into clathrin-coated pits [Homo sapiens] [Reaction:8866269] ARRB bind GPCRs [Homo sapiens] [Reaction:8863472] DAB2 binds LRP2 [Homo sapiens] [Reaction:8866279] Epsin family proteins bind ubiquitinated cargo [Homo sapiens] [Reaction:8863471] LDLR is bound by DAB2 and ARH [Homo sapiens] [Reaction:8867613] PICALM binds R-SNAREs [Homo sapiens] [Reaction:8863463] STON2 binds SYT proteins [Homo sapiens] [Reaction:8856813] AAK1 phosphorylates AP-2 mu subunit at T156 [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:8870617] Antonescu, Costin N, 2016-05-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873354] R-HSA-8868071.3
summation	[Summation:8868059] PIK3C2A is a member of the class II PI 3 kinases, and phosph...
(hasEvent)	[Pathway:8856828] Clathrin-mediated endocytosis [Homo sapiens]
(precedingEvent)	[Reaction:8867754] F- and N- BAR domain proteins bind the clathrin-coated pit [Homo sapiens] [Reaction:8868072] Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 [Homo sapiens]
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No pathways have been reviewed or authored by Clathrin recruits PIK3C2A (8868071)