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Details on Person PIP5K1C phosphorylates PI(4)P to PI(4,5)P2

Class:Id	Reaction:8868066
_displayName	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2
_doRelease	TRUE
_timestamp	2016-05-19 16:46:07
authored	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
catalystActivity	[CatalystActivity:8868067] 1-phosphatidylinositol-4-phosphate 5-kinase activity of PIP5K1C [cytosol]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8868065] Rothfels, Karen, 2016-04-18
edited	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
input	[SimpleEntity:392417] PI4P [plasma membrane] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1660523] Phosphoinositides in cell regulation and membrane dynamics [LiteratureReference:8868023] Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes [LiteratureReference:8868032] Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis [LiteratureReference:8867986] Clathrin regulates the association of PIPKIgamma661 with the AP-2 adaptor beta2 appendage [LiteratureReference:8867983] BAR domain scaffolds in dynamin-mediated membrane fission
modified	[InstanceEdit:8870651] Rothfels, Karen, 2016-05-10 [InstanceEdit:8870663] Rothfels, Karen, 2016-05-10 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2
output	[SimpleEntity:179856] PI(4,5)P2 [plasma membrane] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:8856808] Recruitment of AP-2 complex and clathrin [Homo sapiens] [Reaction:8862280] FCHo proteins bind nascent clathrin-coated pit [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:8870617] Antonescu, Costin N, 2016-05-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873355] R-HSA-8868066.3
summation	[Summation:8868057] Plasma membrane enrichment of PI(4,5)P2 is maintained in par...
(hasEvent)	[Pathway:8856828] Clathrin-mediated endocytosis [Homo sapiens]
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No pathways have been reviewed or authored by PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (8868066)