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Details on Person Binding of VENTX to the p16-INK4A-specific CDKN2A promoter s...
| Class:Id | Summation:8867907 |
|---|---|
| _displayName | Binding of VENTX to the p16-INK4A-specific CDKN2A promoter s... |
| _timestamp | 2016-04-18 14:23:36 |
| created | [InstanceEdit:8867908] Orlic-Milacic, Marija, 2016-04-18 |
| literatureReference | [LiteratureReference:8853914] VentX trans-activates p53 and p16ink4a to regulate cellular senescence [LiteratureReference:8853934] Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells |
| text | Binding of VENTX to the p16-INK4A-specific CDKN2A promoter stimulates p16-INK4A expression. p16-INK4A acts as an inhibitor of cyclin-dependent kinases CDK4 and CDK6 and prevents CDK4/6-mediated inactivation of the RB1 tumor suppressor. Up-regulation of p16-INK4A contributes to VENTX-mediated cell cycle arrest (Wu et al. 2011). VENTX-mediated cell cycle arrest is implicated as an important step in differentiation of human hematopoietic cells (Gao et al. 2012). |
| (summation) | [BlackBoxEvent:8853921] VENTX stimulates p16-INK4A transcription [Homo sapiens] |
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No pathways have been reviewed or authored by Binding of VENTX to the p16-INK4A-specific CDKN2A promoter s... (8867907)
