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Details on Person Binding of VENTX to the promoter of the TP53 (p53) gene stim...

Class:Id	Summation:8867902
_displayName	Binding of VENTX to the promoter of the TP53 (p53) gene stim...
_timestamp	2019-11-05 19:22:18
created	[InstanceEdit:8867903] Orlic-Milacic, Marija, 2016-04-18
literatureReference	[LiteratureReference:8853914] VentX trans-activates p53 and p16ink4a to regulate cellular senescence [LiteratureReference:8853934] Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells
modified	[InstanceEdit:8867905] Orlic-Milacic, Marija, 2016-04-18 [InstanceEdit:8867965] Orlic-Milacic, Marija, 2016-04-18 [InstanceEdit:9666681] Orlic-Milacic, Marija, 2019-11-05
text	Binding of VENTX to the promoter of the TP53 (p53) gene stimulates TP53 transcription, resulting in cell cycle arrest that depends on the expression of the downstream TP53 target CDKN1A (Wu et al. 2011). VENTX-mediated cell cycle arrest is implicated as an important step in differentiation of human hematopoietic cells (Gao et al. 2012).
(summation)	[BlackBoxEvent:8853911] VENTX stimulates TP53 gene expression [Homo sapiens]
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