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Details on Person Mid1-interacting protein 1 (MID1IP1, aka MIG12, SPOT14R, S14...
| Class:Id | Summation:8867332 |
|---|---|
| _displayName | Mid1-interacting protein 1 (MID1IP1, aka MIG12, SPOT14R, S14... |
| _timestamp | 2023-02-17 21:17:45 |
| created | [InstanceEdit:8867333] Jassal, Bijay, 2016-04-07 |
| modified | [InstanceEdit:8867526] Jassal, Bijay, 2016-04-15 [InstanceEdit:8876895] Jassal, Bijay, 2016-06-17 [InstanceEdit:9828803] Orlic-Milacic, Marija, 2023-02-17 |
| text | Mid1-interacting protein 1 (MID1IP1, aka MIG12, SPOT14R, S14R) plays a role in the regulation of lipogenesis in the liver. It is rapidly upregulated by processes that induce lipogenesis (enhanced glucose metabolism, thyroid hormone administration) (Tsatsos et al. 2008). MID1IP1 forms a heterodimer with thyroid hormone-inducible hepatic protein (THRSP, aka SPOT14, S14), proposed to play the same role in lipogenesis as MID1IP1 (Aipoalani et al. 2010). This complex can polymerize acetyl-CoA carboxylases 1 and 2 (ACACA and B), the first committed enzymes in fatty acid (FA) synthesis. Polymerization enhances ACACA and ACACB enzyme activities (Kim et al. 2010, Park et al. 2013). |
| (summation) | [Reaction:8866941] MID1IP1 binds THRSP [Homo sapiens] [Polymerisation:8867342] MID1IP1:THRSP polymerizes ACACB - catalyst used as regulator now, do not release [Homo sapiens] |
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No pathways have been reviewed or authored by Mid1-interacting protein 1 (MID1IP1, aka MIG12, SPOT14R, S14... (8867332)
