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Details on Person EGFR binds EPS15, EPN1, EPS15L1

Class:IdReaction:8867044
_displayNameEGFR binds EPS15, EPN1, EPS15L1
_doReleaseTRUE
_timestamp2016-05-19 16:46:23
authored[InstanceEdit:8866957] Rothfels, Karen, 2016-04-05
compartment[Compartment:876] plasma membrane
created[InstanceEdit:8867043] Rothfels, Karen, 2016-04-05
edited[InstanceEdit:8866957] Rothfels, Karen, 2016-04-05
input[Complex:182946] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] [Homo sapiens]
[Complex:182947] EPS15:HGS:STAM [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:182952] EPN1 [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:182937] EPS15L1 [plasma membrane] [Homo sapiens]
[SimpleEntity:179856] PI(4,5)P2 [plasma membrane]
isChimericFALSE
literatureReference[LiteratureReference:8866989] Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis
[LiteratureReference:8867021] Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference
[LiteratureReference:8867017] Eps15: a multifunctional adaptor protein regulating intracellular trafficking
[LiteratureReference:8867012] Epsin 1 is involved in recruitment of ubiquitinated EGF receptors into clathrin-coated pits
[LiteratureReference:8867004] Mapping of Eps15 domains involved in its targeting to clathrin-coated pits
[LiteratureReference:183040] Clathrin-independent endocytosis of ubiquitinated cargos
modified[InstanceEdit:8869710] Rothfels, Karen, 2016-05-06
[InstanceEdit:8871616] Weiser, JD
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameEGFR binds EPS15, EPN1, EPS15L1
output[Complex:8867034] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2016-06-15
reviewed[InstanceEdit:8869706] Chen, Guang-Chao, 2016-05-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8873421] R-HSA-8867044.3
summation[Summation:8867045] EH-containing proteins such as EPS15, EPN1 and EPS15L1 are r...
(hasEvent)[Pathway:182971] EGFR downregulation [Homo sapiens]
(precedingEvent)[Reaction:8867041] EGFR phosphorylates EPS15 [Homo sapiens]
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No pathways have been reviewed or authored by EGFR binds EPS15, EPN1, EPS15L1 (8867044)