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Details on Person CFTR F508del is degraded by the 26S proteasome

Class:Id	BlackBoxEvent:8866858
_displayName	CFTR F508del is degraded by the 26S proteasome
_doRelease	TRUE
_timestamp	2019-01-15 13:50:51
authored	[InstanceEdit:8866543] Rothfels, Karen, 2016-04-01 [InstanceEdit:8866556] Rothfels, Karen, 2016-04-01
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8866859] Rothfels, Karen, 2016-04-04
disease	[Disease:5678942] cystic fibrosis
edited	[InstanceEdit:8866543] Rothfels, Karen, 2016-04-01 [InstanceEdit:8866556] Rothfels, Karen, 2016-04-01
entityFunctionalStatus	[EntityFunctionalStatus:9630131] gain_of_function of ub-CFTR F508del [cytosol]
input	[Complex:8866844] ub-CFTR F508del [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8866505] RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)
modified	[InstanceEdit:8868738] Rothfels, Karen, 2016-04-22 [InstanceEdit:8871312] Rothfels, Karen, 2016-05-13 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9630135] Rothfels, Karen, 2018-11-29 [InstanceEdit:9634774] Rothfels, Karen, 2019-01-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CFTR F508del is degraded by the 26S proteasome
normalReaction	[BlackBoxEvent:8866553] misfolded CFTR is degraded by the 26S proteasome [Homo sapiens]
output	[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
precedingEvent	[Reaction:8866854] VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol [Homo sapiens] [Reaction:8866856] RNF5 and RNF185 ubiquitinate CFTR F508del [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:8868734] D'Eustachio, Peter, 2016-04-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873540] R-HSA-8866858.4
summation	[Summation:8868735] After VCP-mediated translocation to the cytosol, misfolded C...
(hasEvent)	[Pathway:5678895] Defective CFTR causes cystic fibrosis [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778286] Update Tracker - [BlackBoxEvent:8866858] CFTR F508del is degraded by the 26S proteasome - v68:[add_removeOutput]
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No pathways have been reviewed or authored by CFTR F508del is degraded by the 26S proteasome (8866858)