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Details on Person CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation

Class:Id	Reaction:8866857
_displayName	CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation
_doRelease	TRUE
_timestamp	2018-11-29 02:46:06
authored	[InstanceEdit:8866556] Rothfels, Karen, 2016-04-01
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:8866852] Rothfels, Karen, 2016-04-04
disease	[Disease:5678942] cystic fibrosis
edited	[InstanceEdit:8866556] Rothfels, Karen, 2016-04-01
entityFunctionalStatus	[EntityFunctionalStatus:9630127] gain_of_function of CFTR F508del [endoplasmic reticulum membrane]
input	[Complex:8866531] ERAD complex [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:8866834] CFTR F508del [endoplasmic reticulum membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5678961] Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA [LiteratureReference:5678757] Identification of the cystic fibrosis gene: genetic analysis [LiteratureReference:8866482] Biosynthesis of cystic fibrosis transmembrane conductance regulator [LiteratureReference:8866833] The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation [LiteratureReference:8866829] Assembly and misassembly of cystic fibrosis transmembrane conductance regulator: folding defects caused by deletion of F508 occur before and after the calnexin-dependent association of membrane spanning domain (MSD) 1 and MSD2 [LiteratureReference:8866826] A foldable CFTR{Delta}F508 biogenic intermediate accumulates upon inhibition of the Hsc70-CHIP E3 ubiquitin ligase [LiteratureReference:8866509] Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator [LiteratureReference:8866505] RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)
modified	[InstanceEdit:8868737] Rothfels, Karen, 2016-04-22 [InstanceEdit:8871311] Rothfels, Karen, 2016-05-13 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9630135] Rothfels, Karen, 2018-11-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation
normalReaction	[Reaction:8866551] CFTR binds components of the ERAD machinery for ubiquitination and degradation [Homo sapiens]
output	[Complex:8866848] CFTR F508del:ERAD complex [endoplasmic reticulum membrane] [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:8868734] D'Eustachio, Peter, 2016-04-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873425] R-HSA-8866857.4
summation	[Summation:8866853] Deletion of phenylalanine 508 in CFTR is the most prevalent ...
(hasEvent)	[Pathway:5678895] Defective CFTR causes cystic fibrosis [Homo sapiens]
(precedingEvent)	[Reaction:8866856] RNF5 and RNF185 ubiquitinate CFTR F508del [Homo sapiens]
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