Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person RNF5 and RNF185 ubiquitinate CFTR F508del

Class:Id	Reaction:8866856
_displayName	RNF5 and RNF185 ubiquitinate CFTR F508del
_doRelease	TRUE
_timestamp	2019-01-15 13:51:44
authored	[InstanceEdit:8866556] Rothfels, Karen, 2016-04-01
catalystActivity	[CatalystActivity:8866952] ubiquitin protein ligase activity of CFTR F508del:ERAD complex [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:8866852] Rothfels, Karen, 2016-04-04
disease	[Disease:5678942] cystic fibrosis
edited	[InstanceEdit:8866556] Rothfels, Karen, 2016-04-01
entityFunctionalStatus	[EntityFunctionalStatus:9630129] gain_of_function of CFTR F508del:ERAD complex [endoplasmic reticulum membrane]
input	[Complex:8866848] CFTR F508del:ERAD complex [endoplasmic reticulum membrane] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8866505] RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR) [LiteratureReference:8866509] Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator
modified	[InstanceEdit:8866956] Rothfels, Karen, 2016-04-05 [InstanceEdit:8868741] Rothfels, Karen, 2016-04-22 [InstanceEdit:8871317] Rothfels, Karen, 2016-05-13 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9630135] Rothfels, Karen, 2018-11-29 [InstanceEdit:9634784] Rothfels, Karen, 2019-01-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RNF5 and RNF185 ubiquitinate CFTR F508del
normalReaction	[Reaction:8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR [Homo sapiens]
output	[Complex:8866846] ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent	[Reaction:8866857] CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:8868734] D'Eustachio, Peter, 2016-04-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873426] R-HSA-8866856.4
summation	[Summation:8866855] RNF5 and RNF185 ubiquitinate CFTR F508del as part of the ret...
(hasEvent)	[Pathway:5678895] Defective CFTR causes cystic fibrosis [Homo sapiens]
(precedingEvent)	[Reaction:8866854] VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777864] Update Tracker - [Reaction:8866856] RNF5 and RNF185 ubiquitinate CFTR F508del - v68:[add_removeInput]
[Change default viewing format]

No pathways have been reviewed or authored by RNF5 and RNF185 ubiquitinate CFTR F508del (8866856)