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Details on Person VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol

Class:Id	Reaction:8866854
_displayName	VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol
_doRelease	TRUE
_timestamp	2018-11-29 02:46:21
authored	[InstanceEdit:8866543] Rothfels, Karen, 2016-04-01 [InstanceEdit:8866556] Rothfels, Karen, 2016-04-01
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:8866852] Rothfels, Karen, 2016-04-04
disease	[Disease:5678942] cystic fibrosis
edited	[InstanceEdit:8866543] Rothfels, Karen, 2016-04-01 [InstanceEdit:8866556] Rothfels, Karen, 2016-04-01
entityFunctionalStatus	[EntityFunctionalStatus:9630134] gain_of_function of ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane]
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [Complex:8866846] ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5359171] One step at a time: endoplasmic reticulum-associated degradation [LiteratureReference:8866482] Biosynthesis of cystic fibrosis transmembrane conductance regulator
modified	[InstanceEdit:8868744] Rothfels, Karen, 2016-04-22 [InstanceEdit:8871319] Rothfels, Karen, 2016-05-13 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9630135] Rothfels, Karen, 2018-11-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol
normalReaction	[Reaction:8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol [Homo sapiens]
output	[Complex:8866531] ERAD complex [endoplasmic reticulum membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [Complex:8866844] ub-CFTR F508del [cytosol] [Homo sapiens]
precedingEvent	[Reaction:8866856] RNF5 and RNF185 ubiquitinate CFTR F508del [Homo sapiens] [Reaction:8866857] CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:8868734] D'Eustachio, Peter, 2016-04-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873424] R-HSA-8866854.4
summation	[Summation:8868731] Retrotranslocation of the misfolded CFTR F508del likely depe...
(hasEvent)	[Pathway:5678895] Defective CFTR causes cystic fibrosis [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8866858] CFTR F508del is degraded by the 26S proteasome [Homo sapiens]
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No pathways have been reviewed or authored by VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol (8866854)