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Details on Person Deletion of phenylalanine 508 in CFTR is the most prevalent ...
| Class:Id | Summation:8866853 |
|---|---|
| _displayName | Deletion of phenylalanine 508 in CFTR is the most prevalent ... |
| _timestamp | 2016-04-04 17:38:31 |
| created | [InstanceEdit:8866852] Rothfels, Karen, 2016-04-04 |
| modified | [InstanceEdit:8866888] Rothfels, Karen, 2016-04-04 |
| text | Deletion of phenylalanine 508 in CFTR is the most prevalent mutation causing cystic fibrosis (Riordan et al, 1989; Kerem et al, 1989). F508 deletion causes destabilization and subsequent targeting for co-translational degradation by the ER-associated degradation machinery (ERAD). Like misfolded WT CFTR protein, F508del is ubiquitinated by ERAD-associated E3 ligases including RNF5 and RNF 185, targeting it for VCP-mediated retrotranslocation and 26S proteasomal degradation (Meachem et al, 2001; Rosser et al, 2008; Younger et al, 2004; Younger et al, 2006; El Khouri et al, 2013; reviewed in Pranke and Sermet-Gaudelus, 2014). |
| (summation) | [Reaction:8866857] CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation [Homo sapiens] |
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