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Details on Person CFTR F508del:ERAD complex [endoplasmic reticulum membrane]

Class:IdComplex:8866848
_displayNameCFTR F508del:ERAD complex [endoplasmic reticulum membrane]
_timestamp2016-05-19 16:41:40
compartment[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:8866847] Rothfels, Karen, 2016-04-04
disease[Disease:5678942] cystic fibrosis
hasComponent
isChimericFALSE
modified[InstanceEdit:8871616] Weiser, JD
nameCFTR F508del:ERAD complex
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8872181] R-HSA-8866848.2
(diseaseEntity)[EntityFunctionalStatus:9630129] gain_of_function of CFTR F508del:ERAD complex [endoplasmic reticulum membrane]
(input)[Reaction:8866856] RNF5 and RNF185 ubiquitinate CFTR F508del [Homo sapiens]
(output)[Reaction:8866857] CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation [Homo sapiens]
(physicalEntity)[CatalystActivity:8866952] ubiquitin protein ligase activity of CFTR F508del:ERAD complex [endoplasmic reticulum membrane]
(updatedInstance)[_UpdateTracker:9899689] Update Tracker - [Complex:8866848] CFTR F508del:ERAD complex [endoplasmic reticulum membrane] - v67:[updateContainedComponent]
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No pathways have been reviewed or authored by CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (8866848)
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