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Details on Person ub-CFTR F508del [cytosol]

Class:Id	Complex:8866844
_displayName	ub-CFTR F508del [cytosol]
_timestamp	2019-01-15 13:52:30
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8866843] Rothfels, Karen, 2016-04-04
disease	[Disease:5678942] cystic fibrosis
hasComponent	[EntityWithAccessionedSequence:8866838] ub-CFTR F508del [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
modified	[InstanceEdit:8871616] Weiser, JD [InstanceEdit:9634794] Rothfels, Karen, 2019-01-15
name	ub-CFTR F508del
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8872183] R-HSA-8866844.3
(diseaseEntity)	[EntityFunctionalStatus:9630131] gain_of_function of ub-CFTR F508del [cytosol]
(input)	[BlackBoxEvent:8866858] CFTR F508del is degraded by the 26S proteasome [Homo sapiens]
(output)	[Reaction:8866854] VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9897294] Update Tracker - [Complex:8866844] ub-CFTR F508del [cytosol] - v61:[updateContainedComponent] [_UpdateTracker:9900099] Update Tracker - [Complex:8866844] ub-CFTR F508del [cytosol] - v68:[add_removeHasComponent]
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No pathways have been reviewed or authored by ub-CFTR F508del [cytosol] (8866844)