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Details on Person misfolded CFTR is degraded by the 26S proteasome

Class:Id	BlackBoxEvent:8866553
_displayName	misfolded CFTR is degraded by the 26S proteasome
_doRelease	TRUE
_timestamp	2019-01-15 13:52:26
authored	[InstanceEdit:8866543] Rothfels, Karen, 2016-04-01
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8866554] Rothfels, Karen, 2016-04-01
edited	[InstanceEdit:8866543] Rothfels, Karen, 2016-04-01
input	[Complex:8866534] Ub-misfolded nascent CFTR [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8866505] RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)
modified	[InstanceEdit:8866864] Rothfels, Karen, 2016-04-04 [InstanceEdit:8868746] Rothfels, Karen, 2016-04-22 [InstanceEdit:8871321] Rothfels, Karen, 2016-05-13 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9634793] Rothfels, Karen, 2019-01-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	misfolded CFTR is degraded by the 26S proteasome
output	[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
precedingEvent	[Reaction:8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol [Homo sapiens] [Reaction:8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:8868734] D'Eustachio, Peter, 2016-04-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873536] R-HSA-8866553.4
summation	[Summation:8866549] After VCP-mediated translocation to the cytosol, misfolded C...
(hasEvent)	[Pathway:382556] ABC-family protein mediated transport [Homo sapiens]
(normalReaction)	[BlackBoxEvent:8866858] CFTR F508del is degraded by the 26S proteasome [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777951] Update Tracker - [BlackBoxEvent:8866553] misfolded CFTR is degraded by the 26S proteasome - v68:[add_removeOutput]
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No pathways have been reviewed or authored by misfolded CFTR is degraded by the 26S proteasome (8866553)