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Details on Person CFTR binds components of the ERAD machinery for ubiquitination and degradation

Class:Id	Reaction:8866551
_displayName	CFTR binds components of the ERAD machinery for ubiquitination and degradation
_doRelease	TRUE
_timestamp	2016-05-19 16:46:19
authored	[InstanceEdit:8866556] Rothfels, Karen, 2016-04-01
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:8866550] Rothfels, Karen, 2016-04-01
edited	[InstanceEdit:8866556] Rothfels, Karen, 2016-04-01
input	[Complex:8866531] ERAD complex [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:8868730] misfolded CFTR [endoplasmic reticulum membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8866493] Intracellular turnover of cystic fibrosis transmembrane conductance regulator. Inefficient processing and rapid degradation of wild-type and mutant proteins [LiteratureReference:8866491] Degradation of CFTR by the ubiquitin-proteasome pathway [LiteratureReference:8866498] Multiple proteolytic systems, including the proteasome, contribute to CFTR processing [LiteratureReference:8866483] Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP [LiteratureReference:8866478] A principal role for the proteasome in endoplasmic reticulum-associated degradation of misfolded intracellular cystic fibrosis transmembrane conductance regulator [LiteratureReference:5678791] A mutation in the second nucleotide binding fold of the cystic fibrosis gene [LiteratureReference:5359171] One step at a time: endoplasmic reticulum-associated degradation [LiteratureReference:8866509] Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator [LiteratureReference:8866505] RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)
modified	[InstanceEdit:8866861] Rothfels, Karen, 2016-04-04 [InstanceEdit:8868728] Rothfels, Karen, 2016-04-22 [InstanceEdit:8871313] Rothfels, Karen, 2016-05-13 [InstanceEdit:8871323] Rothfels, Karen, 2016-05-13 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CFTR binds components of the ERAD machinery for ubiquitination and degradation
output	[Complex:8866538] misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:8868734] D'Eustachio, Peter, 2016-04-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873406] R-HSA-8866551.3
summation	[Summation:8866552] Up to two thirds of wild-type CFTR is targeted for co-transl...
(hasEvent)	[Pathway:382556] ABC-family protein mediated transport [Homo sapiens]
(normalReaction)	[Reaction:8866857] CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation [Homo sapiens]
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No pathways have been reviewed or authored by CFTR binds components of the ERAD machinery for ubiquitination and degradation (8866551)