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Details on Person RNF5 and RNF185 ubiquitinate misfolded CFTR

Class:IdReaction:8866546
_displayNameRNF5 and RNF185 ubiquitinate misfolded CFTR
_doReleaseTRUE
_timestamp2019-01-15 13:51:49
authored[InstanceEdit:8866556] Rothfels, Karen, 2016-04-01
catalystActivity[CatalystActivity:8866547] ubiquitin protein ligase activity of misfolded CFTR:ERAD complex [endoplasmic reticulum membrane]
compartment[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:8866543] Rothfels, Karen, 2016-04-01
edited[InstanceEdit:8866866] Rothfels, Karen, 2016-04-04
input[Complex:8866538] misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:8866505] RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)
[LiteratureReference:8866509] Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator
modified[InstanceEdit:8866867] Rothfels, Karen, 2016-04-04
[InstanceEdit:8868742] Rothfels, Karen, 2016-04-22
[InstanceEdit:8871318] Rothfels, Karen, 2016-05-13
[InstanceEdit:8871616] Weiser, JD
[InstanceEdit:9634785] Rothfels, Karen, 2019-01-15
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameRNF5 and RNF185 ubiquitinate misfolded CFTR
output[Complex:8866535] Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] [Homo sapiens]
releaseDate2016-06-15
reviewed[InstanceEdit:8868734] D'Eustachio, Peter, 2016-04-22
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8873405] R-HSA-8866546.4
summation[Summation:8866545] RNF5 and RNF185 ubiquitinate misfolded CFTR as part of the r...
(hasEvent)[Pathway:382556] ABC-family protein mediated transport [Homo sapiens]
(normalReaction)[Reaction:8866856] RNF5 and RNF185 ubiquitinate CFTR F508del [Homo sapiens]
(precedingEvent)[Reaction:8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778389] Update Tracker - [Reaction:8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR - v68:[add_removeInput]
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No pathways have been reviewed or authored by RNF5 and RNF185 ubiquitinate misfolded CFTR (8866546)
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