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Details on Person RNF5 and RNF185 ubiquitinate misfolded CFTR as part of the r...
| Class:Id | Summation:8866545 |
|---|---|
| _displayName | RNF5 and RNF185 ubiquitinate misfolded CFTR as part of the r... |
| _timestamp | 2016-04-04 17:33:04 |
| created | [InstanceEdit:8866543] Rothfels, Karen, 2016-04-01 |
| modified | [InstanceEdit:8866865] Rothfels, Karen, 2016-04-04 |
| text | RNF5 and RNF185 ubiquitinate misfolded CFTR as part of the retrotranslocon that targets the receptor for degradation through the ERAD pathway. Both depletion of the E3 ligases by siRNA and expression of a catalytically inactive form of the enzyme strongly inhibits CFTR degradation (El Khouri et al, 2013; Younger et al, 2006). |
| (summation) | [Reaction:8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by RNF5 and RNF185 ubiquitinate misfolded CFTR as part of the r... (8866545)
