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Details on Person VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol

Class:Id	Reaction:8866542
_displayName	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
_doRelease	TRUE
_timestamp	2016-05-19 16:46:20
authored	[InstanceEdit:8866543] Rothfels, Karen, 2016-04-01
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:8866543] Rothfels, Karen, 2016-04-01
edited	[InstanceEdit:8866543] Rothfels, Karen, 2016-04-01
input	[Complex:8866535] Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5359171] One step at a time: endoplasmic reticulum-associated degradation [LiteratureReference:8866482] Biosynthesis of cystic fibrosis transmembrane conductance regulator
modified	[InstanceEdit:8866866] Rothfels, Karen, 2016-04-04 [InstanceEdit:8868745] Rothfels, Karen, 2016-04-22 [InstanceEdit:8871320] Rothfels, Karen, 2016-05-13 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
output	[Complex:8866531] ERAD complex [endoplasmic reticulum membrane] [Homo sapiens] [Complex:8866534] Ub-misfolded nascent CFTR [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:8868734] D'Eustachio, Peter, 2016-04-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873407] R-HSA-8866542.3
summation	[Summation:8866544] Retrotranslocation of the misfolded CFTR likely depends on t...
(hasEvent)	[Pathway:382556] ABC-family protein mediated transport [Homo sapiens]
(normalReaction)	[Reaction:8866854] VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8866553] misfolded CFTR is degraded by the 26S proteasome [Homo sapiens]
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