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Details on Person RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)

Class:Id	LiteratureReference:8866505
_displayName	RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)
_timestamp	2016-04-01 20:17:10
author	[Person:8866504] El Khouri, Elma [Person:8866501] Le Pavec, Gwena�lle [Person:8866506] Toledano, Michel B [Person:8866503] Delaunay-Moisan, Agn�s
created	[InstanceEdit:8866502] Rothfels, Karen, 2016-04-01
journal	J. Biol. Chem.
pages	31177-91
pubMedIdentifier	24019521
title	RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)
volume	288
year	2013
(literatureReference)	[Reaction:8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR [Homo sapiens] [Reaction:8866551] CFTR binds components of the ERAD machinery for ubiquitination and degradation [Homo sapiens] [BlackBoxEvent:8866553] misfolded CFTR is degraded by the 26S proteasome [Homo sapiens] [Reaction:8866856] RNF5 and RNF185 ubiquitinate CFTR F508del [Homo sapiens] [Reaction:8866857] CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation [Homo sapiens] [BlackBoxEvent:8866858] CFTR F508del is degraded by the 26S proteasome [Homo sapiens]
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