Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)

Class:Id	Reaction:8866405
_displayName	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)
_doRelease	TRUE
_timestamp	2016-11-10 00:55:05
catalystActivity	[CatalystActivity:8866406] ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor of RNR (M1M2B) [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8866407] D'Eustachio, Peter, 2016-03-31
input	[SimpleEntity:8866401] NDP(3-) [cytosol] [EntityWithAccessionedSequence:55729] GLRX [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:111731] Structure and function of the radical enzyme ribonucleotide reductase [LiteratureReference:111733] Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells [LiteratureReference:111723] Thioredoxin and glutaredoxin systems [LiteratureReference:8866393] Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage [LiteratureReference:8866463] Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells [LiteratureReference:111734] Cross-talk between the allosteric effector-binding sites in mouse ribonucleotide reductase [LiteratureReference:111749] In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase [LiteratureReference:111743] The NMR solution structure of human glutaredoxin in the fully reduced form [LiteratureReference:111775] A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage [LiteratureReference:8866460] Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductase [LiteratureReference:499990] A dityrosyl-diiron radical cofactor center is essential for human ribonucleotide reductases
modified	[InstanceEdit:8866409] D'Eustachio, Peter, 2016-03-31 [InstanceEdit:8866465] D'Eustachio, Peter, 2016-04-01 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O
output	[SimpleEntity:8866399] dNDP(3-) [cytosol] [EntityWithAccessionedSequence:111740] 2xHC-GLRX [cytosol] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:111746] glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) [Homo sapiens] [BlackBoxEvent:5632892] TP53 stimulates transcription of RRM2B gene [Homo sapiens] [Reaction:5632887] TP53 binds the RRM2B gene [Homo sapiens]
regulatedBy	[NegativeRegulation:8866419] Negative regulation by 'dATP [cytosol]' [PositiveRegulation:8866467] Positive regulation by 'ATP [cytosol]'
releaseDate	2016-06-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873408] R-HSA-8866405.5
summation	[Summation:8866464] Ribonucleotide reductase (RNR (M1M2B)) catalyzes the reducti...
(hasEvent)	[Pathway:499943] Interconversion of nucleotide di- and triphosphates [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (8866405)