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Details on Person AP-2 directly binds some endocytic cargo

Class:Id	Reaction:8866277
_displayName	AP-2 directly binds some endocytic cargo
_doRelease	TRUE
_timestamp	2020-05-28 13:41:35
authored	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8866272] Rothfels, Karen, 2016-03-29
edited	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
input	[Complex:167712] AP-2 Complex [cytosol] [Homo sapiens] [DefinedSet:8866235] AP-2 cargo [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8864630] Clathrin assembly proteins: affinity purification and a model for coat assembly [LiteratureReference:8856466] Forty Years of Clathrin-coated Vesicles [LiteratureReference:8864672] Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis [LiteratureReference:8864626] Characterization of the signal for rapid internalization of the bovine mannose 6-phosphate/insulin-like growth factor-II receptor [LiteratureReference:8864651] Multiple C-terminal motifs of the 46-kDa mannose 6-phosphate receptor tail contribute to efficient binding of medium chains of AP-2 and AP-3 [LiteratureReference:8864645] Interaction of tyrosine-based sorting signals with clathrin-associated proteins [LiteratureReference:8864613] A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains [LiteratureReference:8864615] A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex [LiteratureReference:8864637] Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex [LiteratureReference:8864661] The gamma/sigma1 and alpha/sigma2 hemicomplexes of clathrin adaptors AP-1 and AP-2 harbor the dileucine recognition site [LiteratureReference:8864631] Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor [LiteratureReference:8864606] A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2 [LiteratureReference:8867567] Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine [LiteratureReference:8867582] Dab2 is a key regulator of endocytosis and post-endocytic trafficking of the cystic fibrosis transmembrane conductance regulator [LiteratureReference:8864622] Cargo recognition in clathrin-mediated endocytosis [LiteratureReference:8870886] Molecular architecture and functional model of the endocytic AP2 complex [LiteratureReference:8870868] Deep-etch visualization of proteins involved in clathrin assembly [LiteratureReference:8864619] A structural explanation for the recognition of tyrosine-based endocytotic signals [LiteratureReference:8863700] Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly [LiteratureReference:8864680] Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly [LiteratureReference:8870863] Adaptors for clathrin coats: structure and function [LiteratureReference:8870883] Integrating molecular and network biology to decode endocytosis
modified	[InstanceEdit:8867620] Rothfels, Karen, 2016-04-15 [InstanceEdit:8870621] Rothfels, Karen, 2016-05-10 [InstanceEdit:8870662] Rothfels, Karen, 2016-05-10 [InstanceEdit:8871199] Rothfels, Karen, 2016-05-13 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9690269] Jassal, Bijay, 2020-05-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AP-2 directly binds some endocytic cargo
output	[Complex:8866238] AP-2:cargo [plasma membrane] [Homo sapiens]
regulatedBy	[NegativeRegulation:9690268] Negative regulation by 'AP2:chlorpromazine [cytosol]'
releaseDate	2016-06-15
reviewed	[InstanceEdit:8870617] Antonescu, Costin N, 2016-05-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873413] R-HSA-8866277.4
summation	[Summation:8866278] AP-2 is a heterotetrameric complex that was originally ident...
(hasEvent)	[Pathway:8856825] Cargo recognition for clathrin-mediated endocytosis [Homo sapiens]
(precedingEvent)	[Reaction:8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776689] Update Tracker - [Reaction:8866277] AP-2 directly binds some endocytic cargo - v74:[addRegulator]
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