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Details on Person CCPs deglutamylate tubulin

Class:Id	Reaction:8866105
_displayName	CCPs deglutamylate tubulin
_doRelease	TRUE
_timestamp	2017-03-22 11:24:09
authored	[InstanceEdit:8956248] Jupe, Steve, 2017-01-18
catalystActivity	[CatalystActivity:8866087] metallocarboxypeptidase activity of CCPs [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8866122] Jupe, Steve, 2016-03-29
edited	[InstanceEdit:8954333] D'Eustachio, Peter, 2017-01-06
goBiologicalProcess	[GO_BiologicalProcess:1042460] protein side chain deglutamylation
inferredFrom	[Reaction:8867463] Ccps deglutamylate tubulin [Homo sapiens]
input	[Complex:8982724] Polyglutamylated microtubule [cytosol] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:8866109] A novel subfamily of mouse cytosolic carboxypeptidases [LiteratureReference:8866126] Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs) [LiteratureReference:8866046] Nna1-like proteins are active metallocarboxypeptidases of a new and diverse M14 subfamily [LiteratureReference:8866123] A family of protein-deglutamylating enzymes associated with neurodegeneration [LiteratureReference:8954332] The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids
modified	[InstanceEdit:8866301] Jupe, Steve, 2016-03-30 [InstanceEdit:8867403] Jupe, Steve, 2016-04-14 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8954333] D'Eustachio, Peter, 2017-01-06 [InstanceEdit:8954350] D'Eustachio, Peter, 2017-01-06 [InstanceEdit:8954359] D'Eustachio, Peter, 2017-01-06 [InstanceEdit:8955328] D'Eustachio, Peter, 2017-01-10 [InstanceEdit:8955871] D'Eustachio, Peter, 2017-01-13 [InstanceEdit:8956249] D'Eustachio, Peter, 2017-01-18 [InstanceEdit:8982723] Jupe, Steve, 2017-03-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CCPs deglutamylate tubulin
output	[Complex:190599] Microtubule [cytosol] [Homo sapiens] [SimpleEntity:29404] L-Glu [cytosol]
releaseDate	2017-03-27
reviewed	[InstanceEdit:8956247] Jassal, Bijay, 2017-01-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8920351] R-HSA-8866105.3
summation	[Summation:8954338] Cytosolic carboxypeptidases (CCPs) catalyze the removal of g...
(hasEvent)	[Pathway:8955332] Carboxyterminal post-translational modifications of tubulin [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776567] Update Tracker - [Reaction:8866105] CCPs deglutamylate tubulin - v75:[modifyText] [_UpdateTracker:9781179] Update Tracker - [Reaction:8866105] CCPs deglutamylate tubulin - v61:[add_removeInput, modifyText]
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