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Details on Person GAB1 binds PTPN11

Class:IdReaction:8865994
_displayNameGAB1 binds PTPN11
_doReleaseTRUE
_timestamp2016-08-12 15:49:42
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:8865993] Orlic-Milacic, Marija, 2016-03-28
input[DefinedSet:8851943] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:162563] PTPN11 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:8851912] Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
[LiteratureReference:8866001] Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo
[LiteratureReference:180316] Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2
modified[InstanceEdit:8866337] Orlic-Milacic, Marija, 2016-03-30
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:8931881] Orlic-Milacic, Marija, 2016-07-19
[InstanceEdit:8931945] Orlic-Milacic, Marija, 2016-07-19
[InstanceEdit:8934886] Orlic-Milacic, Marija, 2016-08-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameGAB1 binds PTPN11
output[Complex:8865998] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2016-09-19
reviewed[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11
[InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8904102] R-HSA-8865994.2
summation[Summation:8866000] Phosphorylated tyrosine residues Y627 and Y659 of GAB1 serve...
(hasEvent)[Pathway:8865999] MET activates PTPN11 [Homo sapiens]
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