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Details on Person histone H3K4 methyltransferase activity of RUNX1:Cbfb:KMT2A:Spi1 gene:Nucleosome [nucleoplasm]

Class:IdCatalystActivity:8865521
_displayNamehistone H3K4 methyltransferase activity of RUNX1:Cbfb:KMT2A:Spi1 gene:Nucleosome [nucleoplasm]
_timestamp2024-05-14 19:02:39
activeUnit[EntityWithAccessionedSequence:1183223] KMT2A [nucleoplasm] [Homo sapiens]
activity[GO_MolecularFunction:81583] histone H3K4 methyltransferase activity
created[InstanceEdit:8865524] Orlic-Milacic, Marija, 2016-03-22
modified[InstanceEdit:8955517] Orlic-Milacic, Marija, 2017-01-11
[InstanceEdit:9658105] Weiser, JD, 2019-08-09
[InstanceEdit:9658105] Weiser, JD, 2019-08-09
[InstanceEdit:9658105] Weiser, JD, 2019-08-09
[InstanceEdit:9658105] Weiser, JD, 2019-08-09
[InstanceEdit:9666277] Weiser, JD, 2019-11-04
[InstanceEdit:9666277] Weiser, JD, 2019-11-04
[InstanceEdit:9666277] Weiser, JD, 2019-11-04
[InstanceEdit:9666277] Weiser, JD, 2019-11-04
[InstanceEdit:9676538] Cook, Justin, 2020-02-17
[InstanceEdit:9676538] Cook, Justin, 2020-02-17
[InstanceEdit:9676538] Cook, Justin, 2020-02-17
[InstanceEdit:9676538] Cook, Justin, 2020-02-17
[InstanceEdit:9689079] Cook, Justin, 2020-05-15
[InstanceEdit:9689079] Cook, Justin, 2020-05-15
[InstanceEdit:9909910] Weiser, Joel, 2024-05-14
[InstanceEdit:9909910] Weiser, Joel, 2024-05-14
physicalEntity[Complex:8865516] RUNX1:Cbfb:KMT2A:Spi1 gene:Nucleosome [nucleoplasm] [Homo sapiens]
(catalystActivity)[CatalystActivityReference:9643793] histone methyltransferase activity (H3-K4 specific) of RUNX1:Cbfb:KMT2A:Spi1 gene:Nucleosome [nucleoplasm] The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations
[Reaction:8865525] KTM2A trimethylates nucleosomes at the Spi1 gene locus producing H3K4Me3 mark [Homo sapiens]
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No pathways have been reviewed or authored by histone H3K4 methyltransferase activity of RUNX1:Cbfb:KMT2A:Spi1 gene:Nucleosome [nucleoplasm] (8865521)
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