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Details on Person SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A

Class:Id	BlackBoxEvent:8865505
_displayName	SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A
_doRelease	TRUE
_timestamp	2019-03-10 10:55:19
authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8865502] Orlic-Milacic, Marija, 2016-03-22
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
inferredFrom	[BlackBoxEvent:8865529] Spi1 gene transcription is stimulated by RUNX1:Cbfb:KMT2A [Homo sapiens]
input	[Complex:8865492] SPI1 gene:Nucleosome [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8865478] The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations
modified	[InstanceEdit:8865535] Orlic-Milacic, Marija, 2016-03-22 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8955747] Orlic-Milacic, Marija, 2017-01-13 [InstanceEdit:8956636] Orlic-Milacic, Marija, 2017-01-23 [InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9639379] May, Bruce, 2019-03-10 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A
output	[EntityWithAccessionedSequence:8865503] SPI1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:8865498] KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark [Homo sapiens] [Reaction:8865491] RUNX1:CBFB:KMT2A binds SPI1 (PU.1) gene [Homo sapiens]
regulatedBy	[PositiveRegulation:8865504] Positive regulation by 'RUNX1:CBFB:KMT2A:SPI1 gene:H3K4me3-Nucleosome [nucleoplasm]'
regulationReference	[RegulationReference:9642128] Positive regulation by 'RUNX1:CBFB:KMT2A:SPI1 gene:H3K4me3-Nucleosome [nucleoplasm]' The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations
releaseDate	2017-06-12
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20 [InstanceEdit:9639377] Skokowa, Julia, 2019-03-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8915993] R-HSA-8865505.4
summation	[Summation:8865531] The SPI1 (PU.1) transcription factor represses self renewal ...
(hasEvent)	[Pathway:8939236] RUNX1 regulates transcription of genes involved in differentiation of HSCs [Homo sapiens] [Pathway:9616222] Transcriptional regulation of granulopoiesis [Homo sapiens]
(precedingEvent)	[Reaction:9616214] RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter [Homo sapiens] [Reaction:9617064] SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene [Homo sapiens] [Reaction:9617207] SPI1 (PU.1), CEBPA and DEK bind the promoter of the CSF3R (G-CSFR) gene [Homo sapiens] [BlackBoxEvent:9617238] CSF3R gene transcription is enhanced by SPI1 (PU.1), CEBPA, and DEK [Homo sapiens] [BlackBoxEvent:9634429] CSF3R gene expression is enhanced by SPI1 (PU.1), CEBPA, and DEK [Homo sapiens]
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No pathways have been reviewed or authored by SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A (8865505)