Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person KMT2A (MLL) binds RUNX1

Class:IdReaction:8865482
_displayNameKMT2A (MLL) binds RUNX1
_doReleaseTRUE
_timestamp2017-05-09 14:03:53
authored[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:8865475] Orlic-Milacic, Marija, 2016-03-22
edited[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
input[EntityWithAccessionedSequence:1183223] KMT2A [nucleoplasm] [Homo sapiens]
[Complex:8865330] RUNX1:CBFB [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:8865478] The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations
modified[InstanceEdit:8865510] Orlic-Milacic, Marija, 2016-03-22
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameKMT2A (MLL) binds RUNX1
output[Complex:8865480] RUNX1:CBFB:KMT2A [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2017-06-12
reviewed[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20
[InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8915642] R-HSA-8865482.2
summation[Summation:8865508] Histone methyltransferase KMT2A (MLL) binds to RUNX1 (AML1) ...
(hasEvent)[Pathway:8939236] RUNX1 regulates transcription of genes involved in differentiation of HSCs [Homo sapiens]
(precedingEvent)[Reaction:8865491] RUNX1:CBFB:KMT2A binds SPI1 (PU.1) gene [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by KMT2A (MLL) binds RUNX1 (8865482)