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Details on Person RUNX2 binds CBFB

Class:Id	Reaction:8865425
_displayName	RUNX2 binds CBFB
_doRelease	TRUE
_timestamp	2017-08-09 17:09:56
authored	[InstanceEdit:8865412] Orlic-Milacic, Marija, 2016-03-22
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8865412] Orlic-Milacic, Marija, 2016-03-22
edited	[InstanceEdit:9015316] Orlic-Milacic, Marija, 2017-08-09
inferredFrom	[Reaction:8865408] Cbfb binds Runx2 [Mus musculus]
input	[EntityWithAccessionedSequence:8865293] CBFB [nucleoplasm] [Homo sapiens] [CandidateSet:9007751] RUNX2 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8865398] Cbfbeta interacts with Runx2 and has a critical role in bone development [LiteratureReference:8865422] Core-binding factor beta interacts with Runx2 and is required for skeletal development [LiteratureReference:8865426] Cbfβ deletion in mice recapitulates cleidocranial dysplasia and reveals multiple functions of Cbfβ required for skeletal development [LiteratureReference:8865395] Mutations in the RUNX2 gene in patients with cleidocranial dysplasia [LiteratureReference:9015211] Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia [LiteratureReference:9015201] Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8952931] Orlic-Milacic, Marija, 2016-12-20 [InstanceEdit:9007753] Orlic-Milacic, Marija, 2017-06-02 [InstanceEdit:9009646] Orlic-Milacic, Marija, 2017-06-21 [InstanceEdit:9014260] Orlic-Milacic, Marija, 2017-07-27 [InstanceEdit:9015218] Orlic-Milacic, Marija, 2017-08-09 [InstanceEdit:9015315] Orlic-Milacic, Marija, 2017-08-09 [InstanceEdit:9015316] Orlic-Milacic, Marija, 2017-08-09 [InstanceEdit:9015317] Orlic-Milacic, Marija, 2017-08-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX2 binds CBFB
output	[Complex:8865420] RUNX2:CBFB [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9007999] RUNX2 translocates to the nucleus [Homo sapiens] [BlackBoxEvent:9007686] RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6) [Homo sapiens] [BlackBoxEvent:8939900] RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 [Homo sapiens]
releaseDate	2017-09-12
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8907437] R-HSA-8865425.2
summation	[Summation:8865416] RUNX2 (CBFA1 or AML3) forms a complex with CBFB. RUNX2 gene ...
(hasEvent)	[Pathway:8878166] Transcriptional regulation by RUNX2 [Homo sapiens]
(precedingEvent)	[Reaction:8877941] RUNX2 binds SMAD1 in the nucleus [Homo sapiens] [Reaction:8878257] RUNX2 binds the IHH gene promoter [Homo sapiens] [Reaction:8937864] RUNX2 binds tyrosine phosphorylated YAP1 [Homo sapiens] [Reaction:8938371] RUNX2:CBFB binds the LGALS3 gene promoter [Homo sapiens] [Reaction:8939670] RUNX2:CBFB binds the ITGA5 gene promoter [Homo sapiens] [Reaction:8939833] RUNX2:CBFB binds the ITGBL1 gene promoter [Homo sapiens] [Reaction:8939852] RUNX2 and SP7 bind the UCMA gene promoter [Homo sapiens] [Reaction:8939963] Activated AKT phosphorylates RUNX2 [Homo sapiens] [Reaction:9008412] CDK4 phosphorylates RUNX2 [Homo sapiens] [Reaction:9008433] RUNX2 binds CDKN1A gene promoter [Homo sapiens] List all 14 refering instances
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No pathways have been reviewed or authored by RUNX2 binds CBFB (8865425)