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Details on Person RUNX2:CBFB [nucleoplasm]
Class:Id Complex:8865420
_displayName RUNX2:CBFB [nucleoplasm]
_timestamp 2017-06-02 19:50:28
compartment [Compartment:7660] nucleoplasm
created [InstanceEdit:8865412] Orlic-Milacic, Marija, 2016-03-22
hasComponent
isChimeric FALSE
literatureReference [LiteratureReference:8865398] Cbfbeta interacts with Runx2 and has a critical role in bone development
modified [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8952931] Orlic-Milacic, Marija, 2016-12-20 [InstanceEdit:9007753] Orlic-Milacic, Marija, 2017-06-02
name RUNX2:CBFB
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:8928915] R-HSA-8865420.2
(activeUnit) [PositiveGeneExpressionRegulation:8938383] Positive gene expression regulation by 'RUNX2:CBFB:LGALS3 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:8939661] Positive gene expression regulation by 'RUNX2:CBFB:ITGA5 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:8939869] Positive gene expression regulation by 'RUNX2:CBFB:SP7:UCMA gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9008864] Positive gene expression regulation by 'RUNX2:CBFB:BAX gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9009255] Positive gene expression regulation by 'RUNX2:CBFB:ITGBL1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9009454] Positive gene expression regulation by 'RUNX2:CBFB:SMURF1 gene [nucleoplasm]'
(hasCandidate) [CandidateSet:9008443] (p-S451-RUNX2:CBFB,RUNX2:CBFB,RUNX2:HDAC6) [nucleoplasm] [Homo sapiens]
(hasComponent) [Complex:8877936] RUNX2:CBFB:p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] [Homo sapiens] [Complex:8878255] RUNX2:CBFB:IHH gene [nucleoplasm] [Homo sapiens] [Complex:8937863] RUNX2:CBFB:p-Y-YAP1 [nucleoplasm] [Homo sapiens] [Complex:8938367] RUNX2:CBFB:LGALS3 gene [nucleoplasm] [Homo sapiens] [Complex:8939664] RUNX2:CBFB:ITGA5 gene [nucleoplasm] [Homo sapiens] [Complex:8939834] RUNX2:CBFB:ITGBL1 gene [nucleoplasm] [Homo sapiens] [Complex:8939856] RUNX2:CBFB:SP7:UCMA gene [nucleoplasm] [Homo sapiens] [Complex:9008858] RUNX2:CBFB:BAX gene [nucleoplasm] [Homo sapiens] [Complex:9009447] RUNX2:CBFB:SMURF1 gene [nucleoplasm] [Homo sapiens] [Complex:9793745] RUNX2:CBFB:CDH1 gene [nucleoplasm] [Homo sapiens]
(hasMember) [CandidateSet:9008881] RUNX2:CBFB,p-S451-RUNX2:CBFB,(p-2S-RUNX2:CBFB) [nucleoplasm] [Homo sapiens]
(input) [Reaction:8877941] RUNX2 binds SMAD1 in the nucleus [Homo sapiens] [Reaction:8878257] RUNX2 binds the IHH gene promoter [Homo sapiens] [Reaction:8937864] RUNX2 binds tyrosine phosphorylated YAP1 [Homo sapiens] [Reaction:8938371] RUNX2:CBFB binds the LGALS3 gene promoter [Homo sapiens] [Reaction:8939670] RUNX2:CBFB binds the ITGA5 gene promoter [Homo sapiens] [Reaction:8939833] RUNX2:CBFB binds the ITGBL1 gene promoter [Homo sapiens] [Reaction:8939852] RUNX2 and SP7 bind the UCMA gene promoter [Homo sapiens] [Reaction:8939963] Activated AKT phosphorylates RUNX2 [Homo sapiens] [Reaction:9008412] CDK4 phosphorylates RUNX2 [Homo sapiens] [Reaction:9008832] RUNX2 binds BAX gene promoter [Homo sapiens]
(output) [Reaction:8865425] RUNX2 binds CBFB [Homo sapiens] [Reaction:9008822] PPM1D dephosphorylates RUNX2 [Homo sapiens]
(updatedInstance) [_UpdateTracker:9897741] Update Tracker - [Complex:8865420] RUNX2:CBFB [nucleoplasm] - v62:[add_removeHasComponent]
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Protein identifiers
No pathways have been reviewed or authored by RUNX2:CBFB [nucleoplasm] (8865420)