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Details on Person Diagram of Transcriptional regulation by RUNX1
| Class:Id | PathwayDiagram:8865321 |
|---|---|
| _displayName | Diagram of Transcriptional regulation by RUNX1 |
| _timestamp | 2026-05-11 17:01:21 |
| created | [InstanceEdit:8865316] Orlic-Milacic, Marija, 2016-03-21 |
| height | 1612 |
| modified | [InstanceEdit:8865427] Orlic-Milacic, Marija, 2016-03-22 [InstanceEdit:8865472] Orlic-Milacic, Marija, 2016-03-22 [InstanceEdit:8865488] Orlic-Milacic, Marija, 2016-03-22 [InstanceEdit:8865495] Orlic-Milacic, Marija, 2016-03-22 [InstanceEdit:8865501] Orlic-Milacic, Marija, 2016-03-22 [InstanceEdit:8865506] Orlic-Milacic, Marija, 2016-03-22 [InstanceEdit:8865554] Orlic-Milacic, Marija, 2016-03-22 [InstanceEdit:8865809] Orlic-Milacic, Marija, 2016-03-24 [InstanceEdit:8867499] Orlic-Milacic, Marija, 2016-04-14 [InstanceEdit:8877136] Orlic-Milacic, Marija, 2016-06-20 [InstanceEdit:8877335] Orlic-Milacic, Marija, 2016-06-21 [InstanceEdit:8877342] Orlic-Milacic, Marija, 2016-06-21 [InstanceEdit:8877346] Orlic-Milacic, Marija, 2016-06-21 [InstanceEdit:8877350] Orlic-Milacic, Marija, 2016-06-21 [InstanceEdit:8877353] Orlic-Milacic, Marija, 2016-06-21 [InstanceEdit:8877366] Orlic-Milacic, Marija, 2016-06-22 [InstanceEdit:8877371] Orlic-Milacic, Marija, 2016-06-22 [InstanceEdit:8877377] Orlic-Milacic, Marija, 2016-06-22 [InstanceEdit:8877378] Orlic-Milacic, Marija, 2016-06-22 [InstanceEdit:8877387] Orlic-Milacic, Marija, 2016-06-22 [InstanceEdit:8877388] Orlic-Milacic, Marija, 2016-06-22 [InstanceEdit:8877392] Orlic-Milacic, Marija, 2016-06-22 [InstanceEdit:8877397] Orlic-Milacic, Marija, 2016-06-22 [InstanceEdit:8877398] Orlic-Milacic, Marija, 2016-06-22 [InstanceEdit:8877403] Orlic-Milacic, Marija, 2016-06-22 [InstanceEdit:8877411] Orlic-Milacic, Marija, 2016-06-22 [InstanceEdit:8877416] Orlic-Milacic, Marija, 2016-06-22 [InstanceEdit:8877422] Orlic-Milacic, Marija, 2016-06-22 [InstanceEdit:8877487] Orlic-Milacic, Marija, 2016-06-22 [InstanceEdit:8877501] Orlic-Milacic, Marija, 2016-06-22 [InstanceEdit:8877883] Orlic-Milacic, Marija, 2016-06-28 [InstanceEdit:8877888] Orlic-Milacic, Marija, 2016-06-28 [InstanceEdit:8877912] Orlic-Milacic, Marija, 2016-06-28 [InstanceEdit:8877913] Orlic-Milacic, Marija, 2016-06-28 [InstanceEdit:8877919] Orlic-Milacic, Marija, 2016-06-28 [InstanceEdit:8877925] Orlic-Milacic, Marija, 2016-06-28 [InstanceEdit:8877944] Orlic-Milacic, Marija, 2016-06-28 [InstanceEdit:8877947] Orlic-Milacic, Marija, 2016-06-28 [InstanceEdit:8878019] Orlic-Milacic, Marija, 2016-06-29 [InstanceEdit:8878020] Orlic-Milacic, Marija, 2016-06-29 [InstanceEdit:8878025] Orlic-Milacic, Marija, 2016-06-29 [InstanceEdit:8878058] Orlic-Milacic, Marija, 2016-06-29 [InstanceEdit:8878070] Orlic-Milacic, Marija, 2016-06-29 [InstanceEdit:8878076] Orlic-Milacic, Marija, 2016-06-29 [InstanceEdit:8878124] Orlic-Milacic, Marija, 2016-06-30 [InstanceEdit:8878131] Orlic-Milacic, Marija, 2016-06-30 [InstanceEdit:8878157] Orlic-Milacic, Marija, 2016-06-30 [InstanceEdit:8878164] Orlic-Milacic, Marija, 2016-06-30 [InstanceEdit:8878169] Orlic-Milacic, Marija, 2016-06-30 [InstanceEdit:8878173] Orlic-Milacic, Marija, 2016-06-30 [InstanceEdit:8931998] Orlic-Milacic, Marija, 2016-07-20 [InstanceEdit:8932032] Orlic-Milacic, Marija, 2016-07-20 [InstanceEdit:8932046] Orlic-Milacic, Marija, 2016-07-20 [InstanceEdit:8932073] Orlic-Milacic, Marija, 2016-07-20 [InstanceEdit:8932080] Orlic-Milacic, Marija, 2016-07-20 [InstanceEdit:8932089] Orlic-Milacic, Marija, 2016-07-20 [InstanceEdit:8932096] Orlic-Milacic, Marija, 2016-07-20 [InstanceEdit:8932097] Orlic-Milacic, Marija, 2016-07-20 [InstanceEdit:8934638] Orlic-Milacic, Marija, 2016-08-11 [InstanceEdit:8934714] Orlic-Milacic, Marija, 2016-08-11 [InstanceEdit:8934717] Orlic-Milacic, Marija, 2016-08-11 [InstanceEdit:8935754] Orlic-Milacic, Marija, 2016-08-15 [InstanceEdit:8935977] Orlic-Milacic, Marija, 2016-08-15 [InstanceEdit:8935996] Orlic-Milacic, Marija, 2016-08-15 [InstanceEdit:8936014] Orlic-Milacic, Marija, 2016-08-15 [InstanceEdit:8936021] Orlic-Milacic, Marija, 2016-08-16 [InstanceEdit:8936022] Orlic-Milacic, Marija, 2016-08-16 [InstanceEdit:8936026] Orlic-Milacic, Marija, 2016-08-16 [InstanceEdit:8936027] Orlic-Milacic, Marija, 2016-08-16 [InstanceEdit:8936159] Orlic-Milacic, Marija, 2016-08-17 [InstanceEdit:8936261] Orlic-Milacic, Marija, 2016-08-17 [InstanceEdit:8936269] Orlic-Milacic, Marija, 2016-08-17 [InstanceEdit:8936317] Orlic-Milacic, Marija, 2016-08-17 [InstanceEdit:8936403] Orlic-Milacic, Marija, 2016-08-18 [InstanceEdit:8936462] Orlic-Milacic, Marija, 2016-08-19 [InstanceEdit:8938001] Orlic-Milacic, Marija, 2016-09-07 [InstanceEdit:8938002] Orlic-Milacic, Marija, 2016-09-08 [InstanceEdit:8938032] Orlic-Milacic, Marija, 2016-09-08 [InstanceEdit:8938043] Orlic-Milacic, Marija, 2016-09-08 [InstanceEdit:8938059] Orlic-Milacic, Marija, 2016-09-08 [InstanceEdit:8938066] Orlic-Milacic, Marija, 2016-09-08 [InstanceEdit:8938070] Orlic-Milacic, Marija, 2016-09-08 [InstanceEdit:8938071] Orlic-Milacic, Marija, 2016-09-08 [InstanceEdit:8938136] Orlic-Milacic, Marija, 2016-09-08 [InstanceEdit:8938166] Orlic-Milacic, Marija, 2016-09-08 [InstanceEdit:8938211] Orlic-Milacic, Marija, 2016-09-08 [InstanceEdit:8938215] Orlic-Milacic, Marija, 2016-09-08 [InstanceEdit:8938227] Orlic-Milacic, Marija, 2016-09-08 [InstanceEdit:8938256] Orlic-Milacic, Marija, 2016-09-08 [InstanceEdit:8938344] Orlic-Milacic, Marija, 2016-09-09 [InstanceEdit:8938398] Orlic-Milacic, Marija, 2016-09-09 [InstanceEdit:8938974] Orlic-Milacic, Marija, 2016-09-14 [InstanceEdit:8938985] Orlic-Milacic, Marija, 2016-09-14 [InstanceEdit:8938992] Orlic-Milacic, Marija, 2016-09-14 [InstanceEdit:8938993] Orlic-Milacic, Marija, 2016-09-14 [InstanceEdit:8939076] Orlic-Milacic, Marija, 2016-09-15 [InstanceEdit:8939077] Orlic-Milacic, Marija, 2016-09-15 [InstanceEdit:8939101] Orlic-Milacic, Marija, 2016-09-15 [InstanceEdit:8939105] Orlic-Milacic, Marija, 2016-09-15 [InstanceEdit:8939106] Orlic-Milacic, Marija, 2016-09-15 [InstanceEdit:8939221] Orlic-Milacic, Marija, 2016-09-16 [InstanceEdit:8939255] Orlic-Milacic, Marija, 2016-09-16 [InstanceEdit:8939498] Orlic-Milacic, Marija, 2016-09-19 [InstanceEdit:8939499] Orlic-Milacic, Marija, 2016-09-19 [InstanceEdit:8939500] Orlic-Milacic, Marija, 2016-09-19 [InstanceEdit:8939655] Orlic-Milacic, Marija, 2016-09-20 [InstanceEdit:8955516] Orlic-Milacic, Marija, 2017-01-11 [InstanceEdit:8955907] Orlic-Milacic, Marija, 2017-01-13 [InstanceEdit:8956616] Orlic-Milacic, Marija, 2017-01-23 [InstanceEdit:8956636] Orlic-Milacic, Marija, 2017-01-23 [InstanceEdit:8956674] Orlic-Milacic, Marija, 2017-01-23 [InstanceEdit:8956681] Orlic-Milacic, Marija, 2017-01-23 [InstanceEdit:8956683] Orlic-Milacic, Marija, 2017-01-23 [InstanceEdit:8957250] Orlic-Milacic, Marija, 2017-01-24 [InstanceEdit:8957253] Orlic-Milacic, Marija, 2017-01-24 [InstanceEdit:8957260] Orlic-Milacic, Marija, 2017-01-24 [InstanceEdit:8957263] Orlic-Milacic, Marija, 2017-01-24 [InstanceEdit:8957268] Orlic-Milacic, Marija, 2017-01-24 [InstanceEdit:8957273] Orlic-Milacic, Marija, 2017-01-24 [InstanceEdit:9006679] Orlic-Milacic, Marija, 2017-05-17 [InstanceEdit:9006680] Orlic-Milacic, Marija, 2017-05-17 [InstanceEdit:9030514] Orlic-Milacic, Marija, 2017-11-28 [InstanceEdit:9032357] Orlic-Milacic, Marija, 2017-12-11 [InstanceEdit:9658439] Orlic-Milacic, Marija, 2019-08-14 [InstanceEdit:9763867] D'Eustachio, Peter, 2022-02-07 [InstanceEdit:9988700] Rothfels, Karen, 2026-05-11 |
| representedPathway | [Pathway:8878171] Transcriptional regulation by RUNX1 [Homo sapiens] |
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bounds="813 107 49 19" textPosition="815 106"> <Properties> <displayName>AXIN1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.ProcessNode id="654" reactomeId="195253" position="675 120" bounds="566 83 218 74" textPosition="574 98"> <Properties> <displayName>Degradation of beta-catenin by the destruction complex</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableComplex id="695" reactomeId="8932085" position="911 254" bounds="863 229 97 50" textPosition="864 229" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:ESR1:estrogen:AXIN1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="714" reactomeId="8934704" position="1411 427" bounds="1392 402 38 51" textPosition="1393 429"> <Properties> <displayName>LIFR gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="715" reactomeId="8934703" position="1581 501" bounds="1536 480 91 42" textPosition="1539 486" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:LIFR gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="717" reactomeId="5693181" position="1984 507" bounds="1964 496 40 22" textPosition="1968 496"> <Properties> <displayName>LIFR</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.ProcessNode id="728" reactomeId="8877330" position="1134 648" bounds="1018 604 233 89" textPosition="1037 619"> <Properties> <displayName>RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableGene id="879" reactomeId="8935963" position="1567 327" bounds="1538 302 58 51" textPosition="1547 329"> <Properties> <displayName>TJP1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="880" reactomeId="8935959" position="1654 259" bounds="1609 239 90 41" textPosition="1611 244" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:TJP1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="976" reactomeId="8935981" position="1690 346" bounds="1665 321 51 51" textPosition="1668 348"> <Properties> <displayName>OCLN gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="977" reactomeId="8935979" position="1648 409" bounds="1603 391 91 37" textPosition="1606 392" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:OCLN gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="985" reactomeId="2160944" position="1946 358" bounds="1925 347 43 22" textPosition="1926 347"> <Properties> <displayName>OCLN</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="1067" reactomeId="8935997" position="1417 296" bounds="1387 271 60 51" textPosition="1391 298"> <Properties> <displayName>CLDN5 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1068" reactomeId="8935998" position="1430 236" bounds="1385 218 90 36" textPosition="1387 218" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:CLDN5 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1070" reactomeId="421264" position="1939 205" bounds="1913 194 52 22" textPosition="1915 194"> <Properties> <displayName>CLDN5</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1105" reactomeId="8936023" position="1949 284" bounds="1931 273 37 22" textPosition="1932 273"> <Properties> <displayName>TJP1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableCompartment id="1126" reactomeId="204883" position="1959 279" bounds="1889 171 140 216" textPosition="1912 244" bgColor="250 240 240" lineColor="255 153 102" insets="1889 172 140 215"> <Properties> <displayName>cell junction</displayName> </Properties> <Components> <Component id="985" /> <Component id="1070" /> <Component id="1105" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.Note id="1127" position="1555 51" bounds="1448 40 215 23" textPosition="1497 40"> <Properties> <isChanged>true</isChanged> <displayName>plasma membrane</displayName> </Properties> </org.gk.render.Note> <org.gk.render.RenderableEntitySet id="1136" reactomeId="8937992" position="1217 892" bounds="1186 874 63 37" textPosition="1188 874"> <Properties> <displayName>(PRC1.4,PRC1.5)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1137" reactomeId="8937995" position="1343 899" bounds="1288 881 110 36" textPosition="1290 881" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:(PRC1.4,PRC1.5)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="1138" reactomeId="8936459" position="1522 579" bounds="1422 539 201 80" textPosition="1436 543"> <Properties> <displayName>RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableGene id="1369" reactomeId="8938046" position="966 921" bounds="929 896 74 51" textPosition="929 923"> <Properties> <displayName>SERPINB13 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1370" reactomeId="8938054" position="1039 1043" bounds="1004 1011 71 64" textPosition="1002 1011" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:SERPINB13 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1402" reactomeId="8938045" position="1292 1409" bounds="1256 1398 72 22" textPosition="1256 1398"> <Properties> <displayName>SERPINB13</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableCompartment id="1456" reactomeId="161320" position="1465 1453" bounds="1233 1365 464 176" textPosition="1248 1495" bgColor="250 240 240" lineColor="255 153 102" insets="1245 1374 440 157"> <Properties> <displayName>lysosomal lumen</displayName> </Properties> <Components> <Component id="1402" /> <Component id="1495" /> <Component id="1494" /> <Component id="1496" /> <Component id="1519" /> <Component id="1518" /> <Component id="1520" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="1495" reactomeId="1181226" position="1375 1439" bounds="1354 1428 43 22" textPosition="1356 1428"> <Properties> <displayName>CTSK</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1496" reactomeId="8938113" position="1483 1402" bounds="1445 1385 77 35" textPosition="1448 1384" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CTSK:SERPINB13</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1519" reactomeId="2029110" position="1403 1501" bounds="1361 1489 84 25" textPosition="1365 1490"> <Properties> <displayName>Cathepsin L</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1520" reactomeId="8938111" position="1531 1466" bounds="1490 1446 82 40" textPosition="1493 1450" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SERPINB13:cathepsin L</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1563" reactomeId="5225604" position="657 1268" bounds="617 1237 81 62" textPosition="617 1235" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SWI/SNF chromatin remodelling complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1564" reactomeId="8938220" position="761 1303" bounds="717 1283 88 40" textPosition="718 1287" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:SWI/SNF</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1701" reactomeId="193545" position="1324 801" bounds="1296 790 56 23" textPosition="1298 790"> <Properties> <displayName>CREBBP</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1702" reactomeId="8938230" position="1416 850" bounds="1384 827 64 46" textPosition="1389 823" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:CREBBP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="1704" reactomeId="8938235" position="1524 789" bounds="1498 764 53 51" textPosition="1504 791"> <Properties> <displayName>CSF2 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1705" reactomeId="8938236" position="1667 833" bounds="1628 804 78 59" textPosition="1633 799" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:CREBBP:CSF2 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1707" reactomeId="517562" position="2045 763" bounds="2022 749 47 28" textPosition="2027 752"> <Properties> <displayName>CSF2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="1714" reactomeId="8938366" position="536 1167" bounds="506 1142 60 51" textPosition="508 1169"> <Properties> <displayName>LGALS3 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1715" reactomeId="8938391" position="666 1182" bounds="620 1165 92 35" textPosition="623 1164" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:LGALS3 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1717" reactomeId="879445" position="593 1577" bounds="567 1565 53 25" textPosition="568 1566"> <Properties> <displayName>LGALS3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1718" reactomeId="8938367" position="474 1227" bounds="431 1208 86 38" textPosition="431 1210" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX2:CBFB:LGALS3 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="1719" reactomeId="8878166" position="335 1231" bounds="269 1189 132 85" textPosition="282 1202"> <Properties> <displayName>Transcriptional regulation by RUNX2</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableProtein id="1768" reactomeId="8938902" position="1310 968" bounds="1292 957 36 22" textPosition="1292 957"> <Properties> <displayName>ELF1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1769" reactomeId="8938916" position="1383 1023" bounds="1340 1006 87 34" textPosition="1341 1004" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:ELF1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="1771" reactomeId="8938941" position="1589 1059" bounds="1569 1034 41 51" textPosition="1571 1061"> <Properties> <displayName>IL3 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1772" reactomeId="8938942" position="1715 1002" bounds="1668 983 95 38" textPosition="1671 985" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:ELF1:IL3 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1802" reactomeId="450059" position="2029 1054" bounds="2013 1043 33 22" textPosition="2017 1043"> <Properties> <displayName>IL3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1811" reactomeId="8938898" position="1301 1036" bounds="1283 1025 36 22" textPosition="1283 1025"> <Properties> <displayName>ELF2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1812" reactomeId="8938928" position="1355 1194" bounds="1312 1177 86 35" textPosition="1312 1176" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:ELF2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1828" reactomeId="158583" position="1285 1252" bounds="1264 1241 42 22" textPosition="1265 1241"> <Properties> <displayName>PAX5</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1829" reactomeId="8938948" position="1366 1295" bounds="1321 1278 91 35" textPosition="1324 1277" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:PAX5</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1831" reactomeId="8938964" position="1499 1199" bounds="1443 1161 113 76" textPosition="1457 1160"> <Properties> <displayName>RUNX1:CBFB:ELF1,RUNX1:CBFB:ELF2,RUNX1:CBFB:PAX5</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableGene id="1835" reactomeId="8938968" position="1504 1287" bounds="1478 1262 53 51" textPosition="1486 1289"> <Properties> <displayName>BLK gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1836" reactomeId="8938969" position="1693 1211" bounds="1642 1186 102 50" textPosition="1644 1186" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:ELF,ELF2,PAX5:BLK gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1882" reactomeId="983580" position="1897 1277" bounds="1883 1266 29 22" textPosition="1883 1266"> <Properties> <displayName>BLK</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="2017" reactomeId="8939051" position="782 1205" bounds="757 1180 51 51" textPosition="757 1207"> <Properties> <displayName>PRKCB gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="2018" reactomeId="8939061" position="895 1294" bounds="852 1276 86 36" textPosition="852 1276" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:PRKCB gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2020" reactomeId="58198" position="821 1391" bounds="797 1378 49 26" textPosition="798 1380"> <Properties> <displayName>PRKCB</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.ProcessNode id="2130" reactomeId="8934593" position="754 449" bounds="689 413 130 72" textPosition="690 420"> <Properties> <displayName>Regulation of RUNX1 Expression and Activity</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableGene id="2133" reactomeId="8848151" position="948 1227" bounds="924 1202 48 51" textPosition="924 1229"> <Properties> <displayName>SOCS3 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="2134" reactomeId="8955750" position="1065 1289" bounds="1037 1258 56 63" textPosition="1038 1257" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:SOCS3 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="2136" reactomeId="8936124" position="1178 1176" bounds="1155 1151 47 51" textPosition="1154 1178"> <Properties> <displayName>SOCS4 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="2137" reactomeId="8955821" position="1114 1201" bounds="1086 1168 56 67" textPosition="1087 1171" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:SOCS4 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2146" reactomeId="873794" position="992 1438" bounds="969 1427 46 22" textPosition="969 1427"> <Properties> <displayName>SOCS3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2148" reactomeId="8936109" position="1175 1434" bounds="1152 1423 46 22" textPosition="1152 1423"> <Properties> <displayName>SOCS4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2150" reactomeId="8956524" position="685 728" bounds="651 710 69 36" textPosition="650 710" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TAL1 core complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2151" reactomeId="8956549" position="570 929" bounds="528 904 85 50" textPosition="528 904" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:TAL1 core complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="2160" reactomeId="8956588" position="277 839" bounds="255 814 45 51" textPosition="259 841"> <Properties> <displayName>MYB gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableEntitySet id="2161" reactomeId="8956602" position="449 933" bounds="380 895 138 77" textPosition="382 895" bgColor="204 255 255" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="2162" reactomeId="8956585" position="242 952" bounds="184 928 117 49" textPosition="183 927" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:GATA3-TAL1 core complex:MYB gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2164" reactomeId="992697" position="166 814" bounds="150 803 33 22" textPosition="150 803"> <Properties> <displayName>MYB</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2223" reactomeId="69221" position="640 818" bounds="624 807 33 22" textPosition="624 807" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CAK</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2409" reactomeId="1253322" position="283 612" bounds="264 601 38 22" textPosition="264 601"> <Properties> <displayName>YAP1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2410" reactomeId="8956638" position="282 450" bounds="236 434 92 33" textPosition="239 431" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:YAP1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2411" reactomeId="5686576" position="212 580" bounds="164 569 96 22" textPosition="167 569"> <Properties> <displayName>p-S456-ABL1</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="1.0" relativeY="0.7780359738321738" label="P" description="Ser" trackId="0" reactomeId="5686580" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="2413" reactomeId="8954671" position="198 383" bounds="175 358 46 51" textPosition="178 385"> <Properties> <displayName>ITCH gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="2414" reactomeId="8956650" position="275 281" bounds="231 255 88 52" textPosition="232 257" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:YAP1:ITCH gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2439" reactomeId="975995" position="199 164" bounds="181 153 37 22" textPosition="181 153"> <Properties> <displayName>ITCH</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="2448" reactomeId="29358" position="298 661" bounds="279 650 38 22" textPosition="282 650" /> <org.gk.render.RenderableChemical id="2449" reactomeId="113582" position="313 718" bounds="294 706 38 24" textPosition="297 707"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="2450" reactomeId="8956661" position="253 753" bounds="207 742 93 22" textPosition="208 742"> <Properties> <displayName>p-Y407-YAP1</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.0" relativeY="0.22577937537899317" label="P" description="Tyr" trackId="0" reactomeId="8956662" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2496" reactomeId="6798077" position="107 617" bounds="74 600 67 34" textPosition="76 598" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="2497" reactomeId="8956675" position="125 896" bounds="71 878 109 36" textPosition="78 878" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-Y407-YAP1:TP73 tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2550" reactomeId="8957246" position="83 140" bounds="51 122 64 36" textPosition="52 122" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TP73 Tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2606" reactomeId="8957254" position="285 109" bounds="241 91 89 36" textPosition="241 91" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PolyUb-TP73 tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="2688" reactomeId="113595" position="107 93" bounds="95 82 24 22" textPosition="95 82"> <Properties> <displayName>Ub</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="2697" reactomeId="68819" position="411 74" bounds="355 63 113 22" textPosition="360 63" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>26S proteasome</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="2749" reactomeId="1980143" position="577 31" bounds="519 4 117 55" textPosition="533 9"> <Properties> <displayName>Signaling by NOTCH1</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.ProcessNode id="2751" reactomeId="5693606" position="171 496" bounds="119 466 105 61" textPosition="124 467"> <Properties> <displayName>DNA Double Strand Break Response</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableGene id="2755" reactomeId="2393968" position="954 331" bounds="917 305 75 52" textPosition="917 332"> <Properties> <displayName>GPAM gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="2765" reactomeId="9941736" position="748 776" bounds="729 765 39 23" textPosition="729 765" /> <org.gk.render.RenderableProtein id="2766" reactomeId="8865295" position="748 681" bounds="723 670 50 23" textPosition="723 670" /> <org.gk.render.RenderableComplex id="2767" reactomeId="9988694" position="671 987" bounds="629 976 84 23" textPosition="629 977" bgColor="204 255 255" hideComponents="true" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="34" reactomeId="8865482" points="445 578, 386 588, 372 615" position="386 588" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="35" points="368 566" /> <Input id="6" points="758 617" /> </Inputs> <Outputs> <Output id="36" /> </Outputs> <Properties> <displayName>KMT2A (MLL) binds RUNX1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="44" reactomeId="8865491" points="426 641, 425 657, 427 681" position="425 657" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="36" points="401 641" /> <Input id="45" points="455 639" /> </Inputs> <Outputs> <Output id="46" /> </Outputs> <Properties> <displayName>RUNX1:CBFB:KMT2A binds SPI1 (PU.1) gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="56" reactomeId="8865498" points="429 745, 429 767, 429 791" position="429 767" lineWidth="1.0"> <Inputs> <Input id="57" stoichiometry="6" points="469 745" /> <Input id="46" points="429 724" /> </Inputs> <Outputs> <Output id="58" points="431 822" /> <Output id="59" stoichiometry="6" points="470 794" /> </Outputs> <Catalysts> <Catalyst id="46" points="416 724, 401 742" /> </Catalysts> <Properties> <displayName>KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="67" reactomeId="8865505" points="545 640, 577 643, 634 649" position="577 643" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="45" /> </Inputs> <Outputs> <Output id="68" /> </Outputs> <Activators> <Activator id="58" points="508 834, 565 821" /> </Activators> <Properties> <displayName>SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="314" reactomeId="8877879" points="1405 756, 1435 761, 1494 732" position="1435 761" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="315" points="1418 685" /> <Input id="108" points="1337 749" /> </Inputs> <Outputs> <Output id="316" /> </Outputs> <Properties> <displayName>RUNX1 and FOXP3 bind the RSPO3 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="325" reactomeId="8877884" points="1418 685, 1533 642, 2010 615" position="1533 642" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="315" /> </Inputs> <Outputs> <Output id="326" /> </Outputs> <Activators> <Activator id="316" points="1532 686" /> </Activators> <Properties> <displayName>RUNX1 and FOXP3 stimulate the RSPO3 gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="430" reactomeId="8878054" points="655 579, 562 565, 483 544" position="562 565" lineWidth="1.0"> <Inputs> <Input id="431" stoichiometry="3" points="669 555" /> <Input id="6" points="758 611" /> </Inputs> <Outputs> <Output id="432" stoichiometry="3" points="507 506" /> <Output id="433" points="423 497" /> </Outputs> <Catalysts> <Catalyst id="441" points="575 530" /> </Catalysts> <Properties> <displayName>HIPK2 phosphorylates RUNX1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="437" reactomeId="8878056" points="715 547, 704 511, 601 419" position="704 511" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="438" points="728 543" /> <Input id="6" points="775 601" /> </Inputs> <Outputs> <Output id="439" /> </Outputs> <Properties> <displayName>RUNX1:CBFB binds EP300</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="451" reactomeId="8878050" points="616 476, 594 460, 558 449" position="594 460" lineWidth="1.0"> <Inputs> <Input id="439" points="586 419" /> <Input id="431" stoichiometry="5" points="662 519" /> </Inputs> <Outputs> <Output id="454" points="463 359" /> <Output id="432" stoichiometry="5" points="532 470" /> </Outputs> <Catalysts> <Catalyst id="441" points="582 502" /> </Catalysts> <Properties> <displayName>HIPK2 phosphorylates RUNX1 and EP300</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="471" reactomeId="8931981" points="843 560, 885 539, 926 511" position="885 539" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="472" points="841 400" /> <Input id="6" points="808 601" /> </Inputs> <Outputs> <Output id="473" /> </Outputs> <Properties> <displayName>RUNX1 binds ESR1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="524" reactomeId="8932021" points="1023 347, 1060 323, 1074 288" position="1060 323" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="473" points="963 464" /> <Input id="2755" points="1001 307" /> </Inputs> <Outputs> <Output id="526" /> </Outputs> <Properties> <displayName>RUNX1 and ESR1 bind the GPAM gene enhancer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="527" reactomeId="8932020" points="1001 307, 980 230, 973 161" position="980 230" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2755" /> </Inputs> <Outputs> <Output id="528" /> </Outputs> <Activators> <Activator id="526" points="1027 244" /> </Activators> <Properties> <displayName>GPAM gene expression is stimulated by RUNX1 and ESR1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="552" reactomeId="8932037" points="1178 374, 1201 347, 1235 286" position="1201 347" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="553" points="1144 320" /> <Input id="473" points="993 464" /> </Inputs> <Outputs> <Output id="554" /> </Outputs> <Properties> <displayName>RUNX1 and ESR1 bind the KCTD6 gene enhancer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="579" reactomeId="8932033" points="1144 320, 1164 244, 1205 174" position="1164 244" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="553" /> </Inputs> <Outputs> <Output id="580" /> </Outputs> <Activators> <Activator id="554" points="1197 250" /> </Activators> <Properties> <displayName>KCTD6 gene expression is stimulated by RUNX1 and ESR1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="623" reactomeId="8932070" points="833 316, 725 325, 709 263" position="725 325" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="472" points="838 358" /> <Input id="624" points="825 255" /> </Inputs> <Outputs> <Output id="625" /> </Outputs> <Properties> <displayName>ESR1 binds the AXIN1 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="648" reactomeId="8932076" points="825 255, 826 211, 835 129" position="826 211" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="624" /> </Inputs> <Outputs> <Output id="649" /> </Outputs> <Inhibitors> <Inhibitor id="625" points="765 226" /> </Inhibitors> <Activators> <Activator id="695" points="860 229" /> </Activators> <Properties> <displayName>AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="655" interactionType="Activate" points="810 116, 787 116" position="798 116" lineWidth="2.0"> <Inputs> <Input id="649" /> </Inputs> <Outputs> <Output id="654" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="694" reactomeId="8932084" points="889 341, 906 315, 908 282" position="906 315" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="473" points="944 464" /> <Input id="624" points="825 255" /> </Inputs> <Outputs> <Output id="695" /> </Outputs> <Properties> <displayName>RUNX1 and ESR1 bind the AXIN1 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="713" reactomeId="8934688" points="1190 475, 1367 476, 1533 495" position="1367 476" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="714" points="1439 404" /> <Input id="6" points="832 609" /> </Inputs> <Outputs> <Output id="715" /> </Outputs> <Properties> <displayName>RUNX1:CBFB binds the LIFR gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="716" reactomeId="8934690" points="1439 404, 1586 433, 1961 503" position="1586 433" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="714" /> </Inputs> <Outputs> <Output id="717" /> </Outputs> <Activators> <Activator id="715" points="1582 477" /> </Activators> <Properties> <displayName>LIFR gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="729" interactionType="Activate" points="832 624, 1015 638" position="923 631" lineWidth="2.0"> <Inputs> <Input id="6" /> </Inputs> <Outputs> <Output id="728" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="878" reactomeId="8935960" points="1412 352, 1444 330, 1606 274" position="1444 330" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6" points="832 607" /> <Input id="879" points="1605 304" /> </Inputs> <Outputs> <Output id="880" /> </Outputs> <Properties> <displayName>RUNX1 binds the TJP1 (ZO-1) gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="905" reactomeId="8935972" points="1605 304, 1645 311, 1928 285" position="1645 311" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="879" /> </Inputs> <Outputs> <Output id="1105" /> </Outputs> <Activators> <Activator id="880" points="1650 283" /> </Activators> <Properties> <displayName>TJP1 (ZO-1) gene expression is stimulated by RUNX1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="975" reactomeId="8935980" points="1411 384, 1563 409, 1600 409" position="1563 409" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6" points="832 608" /> <Input id="976" points="1725 323, 1570 377" /> </Inputs> <Outputs> <Output id="977" /> </Outputs> <Properties> <displayName>RUNX1 binds the OCLN gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="984" reactomeId="8935988" points="1725 323, 1790 359, 1922 358" position="1790 359" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="976" /> </Inputs> <Outputs> <Output id="985" /> </Outputs> <Activators> <Activator id="977" points="1697 392" /> </Activators> <Properties> <displayName>OCLN (Occludin) gene expression is stimulated by RUNX1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1066" reactomeId="8936000" points="1334 345, 1347 274, 1390 257" position="1347 274" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1067" points="1456 273, 1381 279" /> <Input id="6" points="832 604" /> </Inputs> <Outputs> <Output id="1068" /> </Outputs> <Properties> <displayName>RUNX1 binds the CLDN5 (Claudin-5) gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1069" reactomeId="8936007" points="1456 273, 1535 272, 1548 234, 1910 206" position="1548 234" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1067" /> </Inputs> <Outputs> <Output id="1070" /> </Outputs> <Activators> <Activator id="1068" points="1478 235" /> </Activators> <Properties> <displayName>CLDN5 (Claudin-5) gene expression is stimulated by RUNX1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1135" reactomeId="8937989" points="1244 854, 1270 863, 1306 878" position="1270 863" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6" points="832 639" /> <Input id="1136" points="1230 868" /> </Inputs> <Outputs> <Output id="1137" /> </Outputs> <Properties> <displayName>RUNX1 binds PRC1 complexes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1139" interactionType="Activate" points="832 612, 1203 506, 1440 509, 1475 536" position="1321 507" lineWidth="2.0"> <Inputs> <Input id="6" /> </Inputs> <Outputs> <Output id="1138" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1368" reactomeId="8938053" points="927 965, 973 1016, 1001 1028" position="973 1016" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6" points="801 643" /> <Input id="1369" points="1012 898, 1009 983" /> </Inputs> <Outputs> <Output id="1370" /> </Outputs> <Properties> <displayName>RUNX1:CBFB binds the SERPINB13 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1401" reactomeId="8938063" points="1012 898, 1140 1065, 1236 1166, 1289 1395" position="1140 1065" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1369" /> </Inputs> <Outputs> <Output id="1402" /> </Outputs> <Inhibitors> <Inhibitor id="1370" points="1078 1050" /> </Inhibitors> <Properties> <displayName>SERPINB13 gene expression is inhibited by RUNX1:CBFB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1494" reactomeId="8938121" points="1358 1402, 1399 1401, 1442 1401" position="1399 1401" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1402" points="1331 1405" /> <Input id="1495" points="1369 1425" /> </Inputs> <Outputs> <Output id="1496" /> </Outputs> <Properties> <displayName>SERPINB13 binds CTSK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1518" reactomeId="8938108" points="1340 1466, 1408 1464, 1487 1465" position="1408 1464" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1402" points="1301 1423" /> <Input id="1519" points="1380 1483" /> </Inputs> <Outputs> <Output id="1520" /> </Outputs> <Properties> <displayName>SERPINB13 binds cathepsin L</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1562" reactomeId="8938217" points="751 1161, 741 1248, 753 1280" position="741 1248" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6" points="793 643" /> <Input id="1563" points="684 1234" /> </Inputs> <Outputs> <Output id="1564" /> </Outputs> <Properties> <displayName>RUNX1 binds the SWI/SNF complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1700" reactomeId="8938231" points="1231 830, 1331 855, 1381 851" position="1331 855" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1701" points="1293 809" /> <Input id="6" points="832 638" /> </Inputs> <Outputs> <Output id="1702" /> </Outputs> <Properties> <displayName>RUNX1:CBFB binds CREBBP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1703" reactomeId="8938228" points="1559 827, 1571 841, 1625 836" position="1571 841" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1702" points="1451 844" /> <Input id="1704" points="1560 766" /> </Inputs> <Outputs> <Output id="1705" /> </Outputs> <Properties> <displayName>RUNX1:CBFB:CREBBP binds the CSF2 (GM-CSF) gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1706" reactomeId="8938251" points="1560 766, 1669 768, 2019 763" position="1669 768" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1704" /> </Inputs> <Outputs> <Output id="1707" /> </Outputs> <Activators> <Activator id="1705" points="1667 801" /> </Activators> <Properties> <displayName>CSF2 (GM-CSF) gene expression is stimulated by RUNX1 and CREBBP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1713" reactomeId="8938389" points="751 1027, 703 1087, 672 1162" position="703 1087" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6" points="793 643" /> <Input id="1714" points="575 1144" /> </Inputs> <Outputs> <Output id="1715" /> </Outputs> <Properties> <displayName>RUNX1:CBFB binds the LGALS3 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1716" reactomeId="8938382" points="575 1144, 589 1227, 592 1562" position="589 1227" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1714" /> </Inputs> <Outputs> <Output id="1717" /> </Outputs> <Activators> <Activator id="1718" points="520 1227" /> <Activator id="1715" points="636 1203" /> </Activators> <Properties> <displayName>LGALS3 gene expression is stimulated by RUNX1 and RUNX2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1720" interactionType="Activate" points="404 1228, 428 1227" position="416 1227" lineWidth="2.0"> <Inputs> <Input id="1719" /> </Inputs> <Outputs> <Output id="1718" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1767" reactomeId="8938913" points="1241 984, 1276 987, 1337 1008" position="1276 987" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6" points="817 643" /> <Input id="1768" points="1289 972" /> </Inputs> <Outputs> <Output id="1769" /> </Outputs> <Properties> <displayName>RUNX1 binds ELF1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1770" reactomeId="8938938" points="1464 1021, 1602 1005, 1665 1003" position="1602 1005" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1769" points="1430 1021" /> <Input id="1771" points="1619 1036" /> </Inputs> <Outputs> <Output id="1772" /> </Outputs> <Properties> <displayName>RUNX1 and ELF1 bind the IL3 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1801" reactomeId="8938981" points="1619 1036, 1719 1060, 2010 1054" position="1719 1060" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1771" /> </Inputs> <Outputs> <Output id="1802" /> </Outputs> <Activators> <Activator id="1772" points="1716 1024" /> </Activators> <Properties> <displayName>IL3 gene transcription is stimulated by RUNX1 and ELF1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1810" reactomeId="8938930" points="1267 1127, 1298 1159, 1326 1174" position="1298 1159" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1811" points="1296 1050" /> <Input id="6" points="811 643" /> </Inputs> <Outputs> <Output id="1812" /> </Outputs> <Properties> <displayName>RUNX1 binds ELF2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1827" reactomeId="8938951" points="1296 1204, 1324 1240, 1352 1275" position="1324 1240" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6" points="810 643" /> <Input id="1828" points="1287 1238" /> </Inputs> <Outputs> <Output id="1829" /> </Outputs> <Properties> <displayName>RUNX1 binds PAX5 (BSAP)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1830" reactomeId="8938965" points="1584 1227, 1608 1228, 1639 1221" position="1608 1228" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1831" points="1562 1217" /> <Input id="1835" points="1540 1264" /> </Inputs> <Outputs> <Output id="1836" /> </Outputs> <Properties> <displayName>RUNX1 and ELF1, ELF2 or PAX5 bind the BLK gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1832" points="1392 1275, 1445 1243" position="1418 1259" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1829" /> </Inputs> <Outputs> <Output id="1831" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1833" points="1394 1043, 1473 1155" position="1433 1099" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1769" /> </Inputs> <Outputs> <Output id="1831" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1834" points="1401 1195, 1437 1196" position="1419 1195" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1812" /> </Inputs> <Outputs> <Output id="1831" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="1881" reactomeId="8938987" points="1540 1264, 1696 1277, 1880 1277" position="1696 1277" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1835" /> </Inputs> <Outputs> <Output id="1882" /> </Outputs> <Activators> <Activator id="1836" points="1694 1239" /> </Activators> <Properties> <displayName>BLK gene expression is stimulated by the complex of RUNX1 and ELF1, ELF2 or PAX5</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2016" reactomeId="8939054" points="782 1109, 856 1211, 886 1273" position="856 1211" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6" points="794 643" /> <Input id="2017" points="817 1182" /> </Inputs> <Outputs> <Output id="2018" /> </Outputs> <Properties> <displayName>RUNX1 binds the PRKCB gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2019" reactomeId="8939066" points="817 1182, 823 1294, 821 1375" position="823 1294" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2017" /> </Inputs> <Outputs> <Output id="2020" /> </Outputs> <Activators> <Activator id="2018" points="849 1294" /> </Activators> <Properties> <displayName>PRKCB gene expression is stimulated by RUNX1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="2131" interactionType="Activate" points="778 488, 791 503, 794 601" position="791 503" lineWidth="2.0"> <Inputs> <Input id="2130" /> </Inputs> <Outputs> <Output id="6" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="2132" reactomeId="8955748" points="912 1055, 1040 1170, 1058 1255" position="1040 1170" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6" points="796 643, 833 1028" /> <Input id="2133" points="981 1204" /> </Inputs> <Outputs> <Output id="2134" /> </Outputs> <Properties> <displayName>RUNX1 binds the SOCS3 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2135" reactomeId="8955822" points="1019 1097, 1068 1130, 1092 1165" position="1068 1130" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6" points="799 643, 894 1017" /> <Input id="2136" points="1211 1153, 1134 1108" /> </Inputs> <Outputs> <Output id="2137" /> </Outputs> <Properties> <displayName>RUNX1 binds the SOCS4 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2145" reactomeId="8955885" points="981 1204, 996 1293, 992 1424" position="996 1293" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2133" /> </Inputs> <Outputs> <Output id="2146" /> </Outputs> <Inhibitors> <Inhibitor id="2134" points="1034 1290" /> </Inhibitors> <Properties> <displayName>SOCS3 gene expression is inhibited by RUNX1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2147" reactomeId="8955893" points="1211 1153, 1213 1256, 1177 1420" position="1213 1256" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2136" /> </Inputs> <Outputs> <Output id="2148" /> </Outputs> <Inhibitors> <Inhibitor id="2137" points="1145 1216" /> </Inhibitors> <Properties> <displayName>SOCS4 gene expression is inhibited by RUNX1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2149" reactomeId="8956568" points="638 686, 610 770, 576 901" position="610 770" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6" points="758 635" /> <Input id="2150" points="664 707" /> </Inputs> <Outputs> <Output id="2151" /> </Outputs> <Activators> <Activator id="2223" points="633 804" /> </Activators> <Properties> <displayName>RUNX1 binds the core TAL1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2159" reactomeId="8956586" points="319 909, 301 904, 272 925" position="301 904" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2160" points="309 816" /> <Input id="2161" points="374 920" /> </Inputs> <Outputs> <Output id="2162" /> </Outputs> <Properties> <displayName>RUNX1-containing TAL1 complex binds the MYB gene enhancer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2163" reactomeId="8956608" points="309 816, 241 801, 186 811" position="241 801" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2160" /> </Inputs> <Outputs> <Output id="2164" /> </Outputs> <Activators> <Activator id="2162" points="241 925" /> </Activators> <Properties> <displayName>MYB gene transcription is stimulated by the RUNX1-containing TAL1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2408" reactomeId="8956639" points="301 531, 242 515, 271 470" position="242 515" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2409" points="285 598" /> <Input id="6" points="758 615" /> </Inputs> <Outputs> <Output id="2410" /> </Outputs> <Inhibitors> <Inhibitor id="2411" points="217 566" /> </Inhibitors> <Properties> <displayName>RUNX1 binds YAP1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2412" reactomeId="8956649" points="274 385, 273 340, 274 310" position="273 340" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2410" points="279 431" /> <Input id="2413" points="230 360" /> </Inputs> <Outputs> <Output id="2414" /> </Outputs> <Properties> <displayName>The complex of RUNX1 and YAP1 binds the ITCH gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2438" reactomeId="8956652" points="230 360, 191 281, 198 178" position="191 281" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2413" /> </Inputs> <Outputs> <Output id="2439" /> </Outputs> <Activators> <Activator id="2414" points="228 281" /> </Activators> <Properties> <displayName>ITCH gene expression is stimulated by RUNX1 and YAP1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2447" reactomeId="8956659" points="261 659, 271 695, 269 715" position="271 695" lineWidth="1.0"> <Inputs> <Input id="2448" points="276 659" /> <Input id="2409" points="277 626" /> </Inputs> <Outputs> <Output id="2449" points="291 716" /> <Output id="2450" points="257 739" /> </Outputs> <Catalysts> <Catalyst id="2411" points="211 594, 205 698" /> </Catalysts> <Properties> <displayName>ABL1 phosphorylates YAP1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2495" reactomeId="8956676" points="119 797, 122 829, 124 875" position="122 829" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2496" points="108 637" /> <Input id="2450" points="219 767" /> </Inputs> <Outputs> <Output id="2497" /> </Outputs> <Properties> <displayName>YAP1 binds TP73</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2549" reactomeId="8957241" points="85 161, 92 199, 106 597" position="92 199" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2550" /> </Inputs> <Outputs> <Output id="2496" /> </Outputs> <Properties> <displayName>TP73 tetramer translocates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2604" reactomeId="8956684" points="158 101, 198 101, 238 104" position="198 101" lineWidth="1.0"> <Inputs> <Input id="2688" stoichiometry="12" points="125 94" /> <Input id="2550" points="118 123" /> </Inputs> <Outputs> <Output id="2606" /> </Outputs> <Catalysts> <Catalyst id="2439" points="198 150" /> </Catalysts> <Properties> <displayName>ITCH polyubiquitinates TP73</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2696" reactomeId="8957265" points="333 114, 416 124, 484 124, 493 47, 134 47, 113 76" position="416 124" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2606" /> </Inputs> <Outputs> <Output id="2688" stoichiometry="12" /> </Outputs> <Catalysts> <Catalyst id="2697" points="412 88" /> </Catalysts> <Properties> <displayName>26S proteasome degrades TP73 polyubiquitinated by ITCH</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="2750" interactionType="Activate" points="221 163, 502 159, 560 62" position="502 159" lineWidth="2.0"> <Inputs> <Input id="2439" /> </Inputs> <Outputs> <Output id="2749" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="2752" interactionType="Activate" points="186 530, 206 566" position="196 548" lineWidth="2.0"> <Inputs> <Input id="2751" /> </Inputs> <Outputs> <Output id="2411" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="2754" interactionType="Activate" points="1209 696, 1278 733" position="1243 714" lineWidth="2.0"> <Inputs> <Input id="728" /> </Inputs> <Outputs> <Output id="108" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="2764" reactomeId="9988697" points="702 815, 697 843, 673 973" position="697 843" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2765" points="734 791" /> <Input id="2766" points="744 696" /> </Inputs> <Outputs> <Output id="2767" /> </Outputs> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process> |
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No pathways have been reviewed or authored by Diagram of Transcriptional regulation by RUNX1 (8865321)
