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Details on Person CDKN1A gene expression is stimulated by TFAP2A and repressed by TFAP2C

Class:Id	BlackBoxEvent:8865256
_displayName	CDKN1A gene expression is stimulated by TFAP2A and repressed by TFAP2C
_doRelease	TRUE
_timestamp	2016-08-19 20:20:07
authored	[InstanceEdit:8864334] Orlic-Milacic, Marija, 2016-03-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8865257] Orlic-Milacic, Marija, 2016-03-21
edited	[InstanceEdit:8864334] Orlic-Milacic, Marija, 2016-03-14
input	[EntityWithAccessionedSequence:3786256] CDKN1A gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8865242] AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression [LiteratureReference:8865250] Dual association by TFAP2A during activation of the p21cip/CDKN1A promoter [LiteratureReference:8865246] AP-2gamma promotes proliferation in breast tumour cells by direct repression of the CDKN1A gene [LiteratureReference:8865262] Histone demethylase KDM5B collaborates with TFAP2C and Myc to repress the cell cycle inhibitor p21(cip) (CDKN1A)
modified	[InstanceEdit:8865283] Orlic-Milacic, Marija, 2016-03-21 [InstanceEdit:8866912] Orlic-Milacic, Marija, 2016-04-04 [InstanceEdit:8869463] Orlic-Milacic, Marija, 2016-05-04 [InstanceEdit:8869468] Orlic-Milacic, Marija, 2016-05-04 [InstanceEdit:8869469] Orlic-Milacic, Marija, 2016-05-04 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:8936493] Orlic-Milacic, Marija, 2016-08-19 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDKN1A gene expression is stimulated by TFAP2A and repressed by TFAP2C
output	[EntityWithAccessionedSequence:182585] CDKN1A [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:8865244] TFAP2A homodimer binds CDKN1A (p21) gene [Homo sapiens] [Reaction:8864278] AP-2 (TFAP2) transcription factors form homo- and heterodimers [Homo sapiens] [Reaction:8865280] TFAP2C homodimer binds the CDKN1A (p21) gene promoter [Homo sapiens] [Reaction:8865265] TFAP2C homodimer binds MYC and KDM5B [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:8865258] Positive gene expression regulation by 'TFAP2A homodimer:CDKN1A gene [nucleoplasm]' [NegativeGeneExpressionRegulation:8865279] Negative gene expression regulation by 'TFAP2C homodimer:MYC:KDM5B:CDKN1A gene [nucleoplasm]'
regulationReference	[RegulationReference:9641874] Positive gene expression regulation by 'TFAP2A homodimer:CDKN1A gene [nucleoplasm]' AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression [RegulationReference:9642436] Negative gene expression regulation by 'TFAP2C homodimer:MYC:KDM5B:CDKN1A gene [nucleoplasm]' Histone demethylase KDM5B collaborates with TFAP2C and Myc to repress the cell cycle inhibitor p21(cip) (CDKN1A)
releaseDate	2016-06-15
reviewed	[InstanceEdit:8869466] Dawid, Igor B, 2016-05-04 [InstanceEdit:8869464] Zarelli, Valeria E, 2016-05-04 [InstanceEdit:8874793] Bogachek, Maria V, 2016-05-17 [InstanceEdit:8874798] Weigel, Ronald J, 2016-05-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873535] R-HSA-8865256.5
summation	[Summation:8865255] The CDKN1A gene encodes cyclin dependent kinase inhibitor al...
(hasEvent)	[Pathway:8866911] TFAP2 (AP-2) family regulates transcription of cell cycle factors [Homo sapiens]
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No pathways have been reviewed or authored by CDKN1A gene expression is stimulated by TFAP2A and repressed by TFAP2C (8865256)