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Details on Person SETD6 methylates RELA in the NFkB complex

Class:Id	Reaction:8865237
_displayName	SETD6 methylates RELA in the NFkB complex
_doRelease	TRUE
_timestamp	2016-07-15 23:49:20
authored	[InstanceEdit:8865236] Jupe, Steve, 2016-03-21
catalystActivity	[CatalystActivity:8865232] protein-lysine N-methyltransferase activity of SETD6 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8865236] Jupe, Steve, 2016-03-21
edited	[InstanceEdit:8878484] Jupe, Steve, 2016-07-06
input	[Complex:177673] NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:8868087] Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling
modified	[InstanceEdit:8865240] Jupe, Steve, 2016-03-21 [InstanceEdit:8868086] Jupe, Steve, 2016-04-19 [InstanceEdit:8878484] Jupe, Steve, 2016-07-06 [InstanceEdit:8878947] Jupe, Steve, 2016-07-14 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SETD6 methylates RELA in the NFkB complex
output	[Complex:8865239] NFkB Complex with MeK310-RELA [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8878946] Cheng, Xiaodong, 2016-07-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8892232] R-HSA-8865237.2
summation	[Summation:8865235] SET domain containing 6 (SETD6) is an N-lysine methyltransfe...
(hasEvent)	[Pathway:3214841] PKMTs methylate histone lysines [Homo sapiens]
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No pathways have been reviewed or authored by SETD6 methylates RELA in the NFkB complex (8865237)