Query author contributions in Reactome
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Details on Person As inferred from the homologous UBA1, activation of ubiquiti...
| Class:Id | Summation:8865095 |
|---|---|
| _displayName | As inferred from the homologous UBA1, activation of ubiquiti... |
| _timestamp | 2016-08-11 01:22:01 |
| created | [InstanceEdit:8865073] May, Bruce, 2016-03-20 |
| modified | [InstanceEdit:8869300] May, Bruce, 2016-04-30 [InstanceEdit:8934572] May, Bruce, 2016-08-11 |
| text | As inferred from the homologous UBA1, activation of ubiquitin by UBA6 (UBE1L1) proceeds through 3 steps: adenylation of ubiquitin, conjugation of ubiquitin from adenyl-ubiquitin to an internal cysteine residue of UBA6, and adenylation of a second molecule of ubiquitin. In the third step, the UBA6-ubiquitin conjugate adenylates the C-terminal glycine of a second ubiquitin molecule. This results in UBA6 loaded with 2 ubiquitin molecules, one of which is conjugated to an internal cysteine residue of UBA6 and one of which is adenylated and non-covalently bound to UBA6 (Jin et al. 2007, Pelzer et al. 2007, reviewed in Groettrup et al. 2008). |
| (summation) | [Reaction:8865050] Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol [Homo sapiens] |
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No pathways have been reviewed or authored by As inferred from the homologous UBA1, activation of ubiquiti... (8865095)
