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Details on Person UBA6 adenylates ubiquitin in the cytosol

Class:Id	Reaction:8865090
_displayName	UBA6 adenylates ubiquitin in the cytosol
_doRelease	TRUE
_timestamp	2016-08-11 01:22:48
authored	[InstanceEdit:8852137] May, Bruce, 2016-01-11
catalystActivity	[CatalystActivity:8865189] ubiquitin activating enzyme activity of UBA6 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8865073] May, Bruce, 2016-03-20
edited	[InstanceEdit:8852137] May, Bruce, 2016-01-11
inferredFrom	[Reaction:8852134] UBA1 adenylates ubiquitin in the cytosol [Homo sapiens]
input	[SimpleEntity:113592] ATP [cytosol] [EntityWithAccessionedSequence:947701] UBA6 [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8852041] Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging [LiteratureReference:8865074] UBE1L2, a novel E1 enzyme specific for ubiquitin [LiteratureReference:8934565] Activating the ubiquitin family: UBA6 challenges the field
modified	[InstanceEdit:8865197] May, Bruce, 2016-03-21 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933465] May, Bruce, 2016-08-04 [InstanceEdit:8934410] May, Bruce, 2016-08-09 [InstanceEdit:8934572] May, Bruce, 2016-08-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	UBA6 adenylates ubiquitin in the cytosol
output	[SimpleEntity:111294] PPi [cytosol] [Complex:8852088] UBA6:ubiquitin adenylate [cytosol] [Homo sapiens]
precedingEvent	[Reaction:8853529] OTULIN,USP5 cleaves UBB yielding ubiquitin [Homo sapiens] [Reaction:8853515] OTULIN,USP5 cleaves UBC yielding ubiquitin [Homo sapiens] [Reaction:8853503] UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin [Homo sapiens] [Reaction:8853514] UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8934570] Azevedo, Jorge E, 2016-08-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8912589] R-HSA-8865090.2
summation	[Summation:8865080] As inferred from the homologous UBA1, activation of ubiquiti...
(hasEvent)	[Pathway:8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes [Homo sapiens]
(precedingEvent)	[Reaction:8865098] UBA6 conjugates ubiquitin to UBA6 in the cytosol [Homo sapiens]
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