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Details on Person UBA1 is located in both the cytoplasm and nucleus (Grenfell ...
| Class:Id | Summation:8865043 |
|---|---|
| _displayName | UBA1 is located in both the cytoplasm and nucleus (Grenfell ... |
| _timestamp | 2016-08-11 01:22:43 |
| created | [InstanceEdit:8865073] May, Bruce, 2016-03-20 |
| modified | [InstanceEdit:8869300] May, Bruce, 2016-04-30 [InstanceEdit:8934572] May, Bruce, 2016-08-11 |
| text | UBA1 is located in both the cytoplasm and nucleus (Grenfell et al. 1994). Activation of ubiquitin by UBA1 proceeds through 3 steps: adenylation of ubiquitin, conjugation of ubiquitin from adenyl-ubiquitin to an internal cysteine residue of UBA1, and adenylation of a second molecule of ubiquitin. In the third step, the UBA1-ubiquitin conjugate adenylates the C-terminal glycine of a second ubiquitin molecule. This results in UBA1 loaded with 2 ubiquitin molecules, one of which is conjugated to an internal cysteine residue of UBA1 and one of which is adenylated and non-covalently bound to UBA1 (Jin et al. 2007, inferred from the rabbit homologue in Haas et al. 1982, Hershko et al. 1983, reviewed in Groettrup et al. 2008) |
| (summation) | [Reaction:8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus [Homo sapiens] |
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No pathways have been reviewed or authored by UBA1 is located in both the cytoplasm and nucleus (Grenfell ... (8865043)
