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Details on Person Activation of ubiquitin by UBA1 proceeds through 3 steps: ad...
| Class:Id | Summation:8865041 |
|---|---|
| _displayName | Activation of ubiquitin by UBA1 proceeds through 3 steps: ad... |
| _timestamp | 2016-08-11 01:21:57 |
| created | [InstanceEdit:8865073] May, Bruce, 2016-03-20 |
| modified | [InstanceEdit:8869300] May, Bruce, 2016-04-30 [InstanceEdit:8934572] May, Bruce, 2016-08-11 |
| text | Activation of ubiquitin by UBA1 proceeds through 3 steps: adenylation of ubiquitin, conjugation of ubiquitin from adenyl-ubiquitin to an internal cysteine residue of UBA1, and adenylation of a second molecule of ubiquitin. In the second step, the thiol group of an internal cysteine residue of UBA1 attacks the acyl-adenyl bond of the C-terminal glycine of adenylated ubiquitin, resulting in a thioester bond between the cysteine residue and the C-terminal glycine of ubiquitin (Jin et al. 2007, inferred from the rabbit homologue in Haas et al. 1982, Hershko et al. 1983, reviewed in Groettrup et al. 2008). |
| (summation) | [Reaction:8852133] UBA1 conjugates ubiquitin to UBA1 in the cytosol [Homo sapiens] |
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No pathways have been reviewed or authored by Activation of ubiquitin by UBA1 proceeds through 3 steps: ad... (8865041)
