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Details on Person HECT-type E3 ubiquitin ligase binds substrate and E2:Ubiquitin in the nucleus

Class:Id	Reaction:8864508
_displayName	HECT-type E3 ubiquitin ligase binds substrate and E2:Ubiquitin in the nucleus
_timestamp	2016-07-15 23:49:00
authored	[InstanceEdit:8864243] May, Bruce, 2016-03-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8864477] May, Bruce, 2016-03-16
edited	[InstanceEdit:8864243] May, Bruce, 2016-03-14
input	[DefinedSet:8852096] HECT-type E3 ubiquitin ligase [nucleoplasm] [Homo sapiens] [Complex:8864193] Ub:E2 [nucleoplasm] [Homo sapiens] [GenomeEncodedEntity:8865558] Substrate of HECT E3 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8865071] Different HECT domain ubiquitin ligases employ distinct mechanisms of polyubiquitin chain synthesis [LiteratureReference:8865162] Characterization of human hect domain family members and their interaction with UbcH5 and UbcH7
modified	[InstanceEdit:8865103] May, Bruce, 2016-03-20 [InstanceEdit:8865169] May, Bruce, 2016-03-21 [InstanceEdit:8865564] May, Bruce, 2016-03-23 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	HECT-type E3 ubiquitin ligase binds substrate and E2:Ubiquitin in the nucleus
output	[Complex:8864497] Substrate:HECT-type E3:E2:Ub [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:8852130] UBA1 conjugates ubiquitin to nuclear E2 enzymes [Homo sapiens] [Reaction:8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8882996] R-HSA-8864508.1
summation	[Summation:8865140] A nuclear HECT-domain E3 ubiquitin ligase binds both an E2:u...
(hasEvent)	[Pathway:8942999] generic ubiquitination reactions
(precedingEvent)	[Reaction:8864531] HECT-type ubiquitin E3 ligase autoubiquitinates in the nucleus [Homo sapiens]
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No pathways have been reviewed or authored by HECT-type E3 ubiquitin ligase binds substrate and E2:Ubiquitin in the nucleus (8864508)