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Details on Person PTPN18 binds ERBB2:EGFR heterodimers

Class:Id	Reaction:8864105
_displayName	PTPN18 binds ERBB2:EGFR heterodimers
_doRelease	TRUE
_timestamp	2024-03-20 23:46:54
authored	[InstanceEdit:8864114] Orlic-Milacic, Marija, 2016-03-11
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8864114] Orlic-Milacic, Marija, 2016-03-11
edited	[InstanceEdit:8934510] Orlic-Milacic, Marija, 2016-08-09
input	[CandidateSet:1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8864101] PTPN18 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8864099] The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933226] Orlic-Milacic, Marija, 2016-08-03 [InstanceEdit:8934526] Orlic-Milacic, Marija, 2016-08-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9866055] Orlic-Milacic, Marija, 2024-03-20
name	PTPN18 binds ERBB2:EGFR heterodimers
negativePrecedingEvent	[NegativePrecedingEvent:9866045] Futile Cycle: ERBB2 promotes PTK6 autophosphorylation [NegativePrecedingEvent:9866039] Futile Cycle: PLCG1 phosphorylation by p-EGFR:p-ERBB2
output	[Complex:8864106] Phosphorylated ERBB2:EGFR heterodimers:PTPN18 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1963582] Trans-autophosphorylation of ERBB2 heterodimers [Homo sapiens] [Reaction:1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 [Homo sapiens] [Reaction:1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers [Homo sapiens] [Reaction:1963586] SRC family kinases phosphorylate ERBB2 [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8934523] Ayoub, Emily, 2016-08-04 [InstanceEdit:8934520] Tremblay, Michel, 2016-08-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8904374] R-HSA-8864105.3
summation	[Summation:8864096] PTPN18 protein tyrosine phosphatase (BDP1) binds ERBB2, acti...
(hasEvent)	[Pathway:8863795] Downregulation of ERBB2 signaling [Homo sapiens]
(precedingEvent)	[Reaction:8864125] PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 [Homo sapiens]
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No pathways have been reviewed or authored by PTPN18 binds ERBB2:EGFR heterodimers (8864105)