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Details on Person PTPN12 dephosphorylates ERBB2 on tyrosine Y1248

Class:Id	Reaction:8863804
_displayName	PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
_doRelease	TRUE
_timestamp	2024-03-20 23:46:51
authored	[InstanceEdit:8863812] Orlic-Milacic, Marija, 2016-03-10
catalystActivity	[CatalystActivity:8863802] protein tyrosine phosphatase activity of PTPN12 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643236] protein tyrosine phosphatase activity of PTPN12 [cytosol] Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:8863812] Orlic-Milacic, Marija, 2016-03-10
edited	[InstanceEdit:8934521] Orlic-Milacic, Marija, 2016-08-09
goBiologicalProcess	[GO_BiologicalProcess:2455327] negative regulation of ERBB signaling pathway
input	[CandidateSet:1963588] p-ERBB2 heterodimers [plasma membrane] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:8863803] Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase [LiteratureReference:8933614] The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif [LiteratureReference:8933605] The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor
modified	[InstanceEdit:8863993] Orlic-Milacic, Marija, 2016-03-10 [InstanceEdit:8864026] Orlic-Milacic, Marija, 2016-03-10 [InstanceEdit:8867968] Orlic-Milacic, Marija, 2016-04-18 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933226] Orlic-Milacic, Marija, 2016-08-03 [InstanceEdit:8934427] Orlic-Milacic, Marija, 2016-08-09 [InstanceEdit:8934526] Orlic-Milacic, Marija, 2016-08-09 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9866055] Orlic-Milacic, Marija, 2024-03-20
name	PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
negativePrecedingEvent	[NegativePrecedingEvent:9866032] Futile Cycle: ERBB2 promotes PTK6 autophosphorylation [NegativePrecedingEvent:9866053] Futile Cycle: PLCG1 phosphorylation by p-EGFR:p-ERBB2
output	[SimpleEntity:29372] Pi [cytosol] [CandidateSet:8863989] Heterodimers of p-ERBB2 dephosphorylated at Y1248 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1963582] Trans-autophosphorylation of ERBB2 heterodimers [Homo sapiens] [Reaction:1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 [Homo sapiens] [Reaction:1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers [Homo sapiens] [Reaction:1963586] SRC family kinases phosphorylate ERBB2 [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8934523] Ayoub, Emily, 2016-08-04 [InstanceEdit:8934520] Tremblay, Michel, 2016-08-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8911801] R-HSA-8863804.4
summation	[Summation:8864023] PTPN12 protein tyrosine phosphatase dephosphorylates activat...
(hasEvent)	[Pathway:8863795] Downregulation of ERBB2 signaling [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9866008] Negative relationship: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 [NegativePrecedingEvent:9866012] Negative relationship: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 [NegativePrecedingEvent:9866015] Negative relationship: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 [NegativePrecedingEvent:9866020] Negative relationship: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 [NegativePrecedingEvent:9866026] Negative relationship: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 [NegativePrecedingEvent:9866033] Negative relationship: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 [NegativePrecedingEvent:9866049] Negative relationship: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
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