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Details on Person protein tyrosine phosphatase activity of PTPN12 [cytosol]

Class:Id	CatalystActivity:8863802
_displayName	protein tyrosine phosphatase activity of PTPN12 [cytosol]
_timestamp	2016-03-10 15:27:53
activeUnit	[EntityWithAccessionedSequence:432933] PTPN12 [cytosol] [Homo sapiens]
activity	[GO_MolecularFunction:11061] protein tyrosine phosphatase activity
created	[InstanceEdit:8863812] Orlic-Milacic, Marija, 2016-03-10
modified	[InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9689079] Cook, Justin, 2020-05-15 [InstanceEdit:9689079] Cook, Justin, 2020-05-15 [InstanceEdit:9715688] Shorser, Solomon, 2021-02-17 [InstanceEdit:9715688] Shorser, Solomon, 2021-02-17 [InstanceEdit:9729976] Shorser, Solomon, 2021-05-05 [InstanceEdit:9729976] Shorser, Solomon, 2021-05-05 [InstanceEdit:9750461] Weiser, JD, 2021-08-11 [InstanceEdit:9750461] Weiser, JD, 2021-08-11 [InstanceEdit:9757984] Weiser, JD, 2021-11-08 [InstanceEdit:9757984] Weiser, JD, 2021-11-08 [InstanceEdit:9767390] Wright, Adam, 2022-02-25 [InstanceEdit:9767390] Wright, Adam, 2022-02-25 [InstanceEdit:9773515] Weiser, Joel, 2022-05-04 [InstanceEdit:9773515] Weiser, Joel, 2022-05-04 [InstanceEdit:9909910] Weiser, Joel, 2024-05-14 [InstanceEdit:9909910] Weiser, Joel, 2024-05-14 [InstanceEdit:9917728] Weiser, Joel, 2024-08-09 [InstanceEdit:9917728] Weiser, Joel, 2024-08-09 [InstanceEdit:9926726] Weiser, Joel, 2024-11-03 [InstanceEdit:9926726] Weiser, Joel, 2024-11-03 [InstanceEdit:9939161] Weiser, Joel, 2025-02-21 [InstanceEdit:9939161] Weiser, Joel, 2025-02-21 [InstanceEdit:9948552] Weiser, Joel, 2025-05-21 [InstanceEdit:9948552] Weiser, Joel, 2025-05-21 [InstanceEdit:9963749] Weiser, Joel, 2025-08-15 [InstanceEdit:9963749] Weiser, Joel, 2025-08-15 [InstanceEdit:9970792] Weiser, Joel, 2025-10-31 [InstanceEdit:9970792] Weiser, Joel, 2025-10-31 [InstanceEdit:9983308] Weiser, Joel, 2026-02-22 [InstanceEdit:9983308] Weiser, Joel, 2026-02-22 [InstanceEdit:9989150] Weiser, Joel, 2026-05-15 [InstanceEdit:9989150] Weiser, Joel, 2026-05-15
physicalEntity	[EntityWithAccessionedSequence:432933] PTPN12 [cytosol] [Homo sapiens]
(catalystActivity)	[Reaction:8863804] PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 [Homo sapiens] [Reaction:8864029] PTPN12 dephosphorylates EGFR at Y1172 (Y1148) [Homo sapiens] [Reaction:8864036] PTPN12 dephosphorylates PDGFRB at Y1021 [Homo sapiens] [Reaction:9846409] GOCAM PTPN12 dephosphorylates EGFR at Y1172 (Y1148) [Homo sapiens] [CatalystActivityReference:9643236] protein tyrosine phosphatase activity of PTPN12 [cytosol] Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase
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No pathways have been reviewed or authored by protein tyrosine phosphatase activity of PTPN12 [cytosol] (8863802)