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Details on Person p25-bound CDK5 phosphorylates CDC25C

Class:Id	Reaction:8863011
_displayName	p25-bound CDK5 phosphorylates CDC25C
_doRelease	TRUE
_timestamp	2016-07-15 23:49:34
authored	[InstanceEdit:8862798] Shah, Kavita, 2016-02-23
catalystActivity	[CatalystActivity:8863661] protein serine/threonine kinase activity of CDK5:p25 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8863015] Orlic-Milacic, Marija, 2016-03-02
disease	[Disease:8863054] Alzheimer's disease
edited	[InstanceEdit:8870548] Orlic-Milacic, Marija, 2016-05-10
input	[EntityWithAccessionedSequence:157879] CDC25C [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:8862800] Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death
modified	[InstanceEdit:8863025] Orlic-Milacic, Marija, 2016-03-02 [InstanceEdit:8863056] Orlic-Milacic, Marija, 2016-03-03 [InstanceEdit:8863659] Orlic-Milacic, Marija, 2016-03-09 [InstanceEdit:8863662] Orlic-Milacic, Marija, 2016-03-09 [InstanceEdit:8863669] Orlic-Milacic, Marija, 2016-03-09 [InstanceEdit:8870556] Orlic-Milacic, Marija, 2016-05-10 [InstanceEdit:8875080] Orlic-Milacic, Marija, 2016-06-01 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p25-bound CDK5 phosphorylates CDC25C
output	[EntityWithAccessionedSequence:8863654] p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:8863013] CDK5 binds p25 [Homo sapiens] [Reaction:8863012] Calpain cleaves p35 to p25 [Homo sapiens]
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8898351] R-HSA-8863011.2
summation	[Summation:8863668] CDK5 activated by binding to p25 phosphorylates CDC25C prote...
(hasEvent)	[Pathway:8862803] Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models [Homo sapiens]
(precedingEvent)	[Reaction:8863667] CDC25C phosphorylated by CDK5:p25 translocates to the nucleus [Homo sapiens]
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No pathways have been reviewed or authored by p25-bound CDK5 phosphorylates CDC25C (8863011)