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Details on Person RING-type E3 ubiquitin ligase transfers Ubiquitin from E2:Ubiquitin directly to substrate protein in the cytosol

Class:Id	Reaction:8862642
_displayName	RING-type E3 ubiquitin ligase transfers Ubiquitin from E2:Ubiquitin directly to substrate protein in the cytosol
_timestamp	2016-07-15 23:49:07
authored	[InstanceEdit:8861822] May, Bruce, 2016-02-21
catalystActivity	[CatalystActivity:8863228] ubiquitin-protein transferase activity of Substrate:RING-type E3:E2:Ub [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8862641] May, Bruce, 2016-02-27
edited	[InstanceEdit:8861822] May, Bruce, 2016-02-21
input	[Complex:8862638] Substrate:RING-type E3:E2:Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:982870] RING domain E3 ubiquitin ligases [LiteratureReference:8865168] RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination [LiteratureReference:8865166] Mechanistic insights into active site-associated polyubiquitination by the ubiquitin-conjugating enzyme Ube2g2 [LiteratureReference:8865153] A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate [LiteratureReference:8865137] Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases [LiteratureReference:8865131] BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer [LiteratureReference:8865125] E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages [LiteratureReference:8865130] Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis
modified	[InstanceEdit:8863235] May, Bruce, 2016-03-05 [InstanceEdit:8864243] May, Bruce, 2016-03-14 [InstanceEdit:8864545] May, Bruce, 2016-03-16 [InstanceEdit:8865169] May, Bruce, 2016-03-21 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	RING-type E3 ubiquitin ligase transfers Ubiquitin from E2:Ubiquitin directly to substrate protein in the cytosol
output	[CandidateSet:8862635] E2 ubiquitin conjugating enzyme [cytosol] [Homo sapiens] [Complex:8863182] RING-type E3:Substrate:Ub [cytosol] [Homo sapiens]
precedingEvent	[Reaction:8862643] RING-type E3 ubiquitin ligase binds substrate protein and E2:Ubiquitin in the cytosol [Homo sapiens] [Reaction:8852129] UBA1 conjugates ubiquitin to cytosolic E2 enzymes [Homo sapiens] [Reaction:8852127] UBA6 conjugates ubiquitin to cytosolic E2 enzymes [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8886490] R-HSA-8862642.1
summation	[Summation:8863229] Really Interesting New Gene (RING) finger E3 ubiquitin ligas...
(hasEvent)	[Pathway:8942999] generic ubiquitination reactions
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