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Details on Person Lysozyme (LYZ), also known as 1,4-beta-N-acetylmuramidase C,...
| Class:Id | Summation:8862352 |
|---|---|
| _displayName | Lysozyme (LYZ), also known as 1,4-beta-N-acetylmuramidase C,... |
| _timestamp | 2016-07-20 22:34:42 |
| created | [InstanceEdit:8862346] Shamovsky, Veronica, 2016-02-26 |
| literatureReference | [LiteratureReference:8862335] Mechanism of lysozyme catalysis: role of ground-state strain in subsite D in hen egg-white and human lysozymes [LiteratureReference:8862326] Lysozyme and microbiota in relation to gingivitis and periodontitis [LiteratureReference:8862328] Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate [LiteratureReference:8862327] Crystallographic studies of the activity of hen egg-white lysozyme [LiteratureReference:8862295] Antimicrobial properties of lysozyme in relation to foodborne vegetative bacteria [LiteratureReference:8862315] Clinical applications of antimicrobial host proteins lactoperoxidase, lysozyme and lactoferrin in xerostomia: efficacy and safety [LiteratureReference:8862342] Lysozyme in breast milk is a selection factor for bifidobacterial colonisation in the infant intestine [LiteratureReference:8862312] Peptidoglycan of Legionella pneumophila: apparent resistance to lysozyme hydrolysis correlates with a high degree of peptide cross-linking [LiteratureReference:8862299] Understanding the Structure-Function Relationship of Lysozyme Resistance in Staphylococcus aureus by Peptidoglycan O-Acetylation Using Molecular Docking, Dynamics, and Lysis Assay [LiteratureReference:8862341] Why are pathogenic staphylococci so lysozyme resistant? The peptidoglycan O-acetyltransferase OatA is the major determinant for lysozyme resistance of Staphylococcus aureus |
| modified | [InstanceEdit:8932099] Shamovsky, Veronica, 2016-07-20 |
| text | Lysozyme (LYZ), also known as 1,4-beta-N-acetylmuramidase C, is a host hydrolytic enzyme with muramidase activity that hydrolyzes (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in the bacterial cell wall peptidoglycan (Schindler M et al. 1977; Surna A et al. 2009). LYZ acts against both gram-positive and gram-negative bacteria such as Peptostreptococcus micros, Eubacterium nodatum, Eikenella corrodens, Fusobacterium periodontium and Campylobacter rectus (Surna A et al. 2009; Tenovuo J 2002). The muramidase activity of LYZ is thought to be more effective against Gram-positive bacteria with their peptidoglycan layer exposed to the extracellular milieu. The detailed mechanism by which LYZ hydrolyses its substrate is described for hen egg-white lysozyme (HEWL) (Blake CC et al. 1967; Vocadlo DJ et al. 2001). Many pathogens such as Streptococcus pneumoniae have evolved lysozyme resistance to prevent peptidoglycan hydrolysis. The primary mechanism for lysozyme resistance in both Gram-positive and Gram-negative organisms appears to be direct modification of peptidoglycan; however, modification of other cell wall-linked components, such as teichoic acid, may also contribute to resistance (Amano K & Williams JC 1983; Bera A et al. 2005; Pushkaran AC et al. 2015). LYZ is found in many human secretions such as tears, milk, mucus and saliva (Surna A et al. 2009; Minami J et al. 2015; Sahin O et al. 2016; Masschalck B & Michiels CW. 2003). |
| (summation) | [BlackBoxEvent:8862320] LYZ hydrolyzes peptidoglycans in the bacterial cell wall [Homo sapiens] |
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