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Details on Person LYZ hydrolyzes peptidoglycans in the bacterial cell wall

Class:Id	BlackBoxEvent:8862320
_displayName	LYZ hydrolyzes peptidoglycans in the bacterial cell wall
_doRelease	TRUE
_timestamp	2023-05-25 21:54:41
authored	[InstanceEdit:6803156] Shamovsky, Veronica, 2015-10-05
catalystActivity	[CatalystActivity:8862351] lysozyme activity of LYZ:PGN [extracellular region]
compartment	[Compartment:984] extracellular region [Compartment:25409] peptidoglycan-based cell wall
created	[InstanceEdit:8862346] Shamovsky, Veronica, 2016-02-26
edited	[InstanceEdit:8935852] Shamovsky, Veronica, 2016-08-15
entityOnOtherCell	[SimpleEntity:6789198] GlcNac-(1-->4)MurNAc-L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2 [peptidoglycan-based cell wall]
input	[Complex:8862293] LYZ:PGN [extracellular region] [Homo sapiens] [SimpleEntity:109276] H2O [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:8862335] Mechanism of lysozyme catalysis: role of ground-state strain in subsite D in hen egg-white and human lysozymes [LiteratureReference:8862326] Lysozyme and microbiota in relation to gingivitis and periodontitis
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8931789] Shamovsky, Veronica, 2016-07-19 [InstanceEdit:8933041] Shamovsky, Veronica, 2016-08-02 [InstanceEdit:8935890] Shamovsky, Veronica, 2016-08-15 [InstanceEdit:8936377] Shamovsky, Veronica, 2016-08-18 [InstanceEdit:9617520] Shamovsky, Veronica, 2018-08-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9836317] D'Eustachio, Peter, 2023-05-25
name	LYZ hydrolyzes peptidoglycans in the bacterial cell wall LYZ hydrolyzes beta 1->4 linkages of between GlcNAc and MurNAc
output	[Complex:6788991] MurNAc:Peptide [peptidoglycan-based cell wall] [SimpleEntity:6788982] betaGlcNAc [peptidoglycan-based cell wall]
precedingEvent	[Reaction:8862300] LYZ binds bacterial peptidoglycan [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8933035] Hains, David S, 2016-08-02 [InstanceEdit:8867536] Jupe, Steve, 2016-04-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8902260] R-HSA-8862320.4
summation	[Summation:8862352] Lysozyme (LYZ), also known as 1,4-beta-N-acetylmuramidase C,...
(hasEvent)	[Pathway:6803157] Antimicrobial peptides [Homo sapiens]
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