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Details on Person FCHo proteins bind nascent clathrin-coated pit

Class:Id	Reaction:8862280
_displayName	FCHo proteins bind nascent clathrin-coated pit
_doRelease	TRUE
_timestamp	2016-09-21 14:22:25
authored	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8862279] Rothfels, Karen, 2016-02-25
edited	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
input	[CandidateSet:8862274] ITSNs [cytosol] [Homo sapiens] [DefinedSet:8862270] FCHO1,2 dimer [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:182920] EPS15 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8862265] REPS1 [cytosol] [Homo sapiens] [Complex:8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8862268] SGIP1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8862229] FCHo proteins are nucleators of clathrin-mediated endocytosis [LiteratureReference:8862217] Early-arriving Syp1p and Ede1p function in endocytic site placement and formation in budding yeast [LiteratureReference:8862244] Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation [LiteratureReference:8862252] Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits [LiteratureReference:8868489] Phosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and size [LiteratureReference:8856473] Molecular mechanism and physiological functions of clathrin-mediated endocytosis [LiteratureReference:8862232] Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature [LiteratureReference:8862200] Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis [LiteratureReference:8870875] Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning [LiteratureReference:8867724] The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex [LiteratureReference:8868547] Two synaptojanin 1 isoforms are recruited to clathrin-coated pits at different stages [LiteratureReference:8870569] Advances in analysis of low signal-to-noise images link dynamin and AP2 to the functions of an endocytic checkpoint [LiteratureReference:8867678] Cargo and dynamin regulate clathrin-coated pit maturation
modified	[InstanceEdit:8870646] Rothfels, Karen, 2016-05-10 [InstanceEdit:8870663] Rothfels, Karen, 2016-05-10 [InstanceEdit:8871208] Rothfels, Karen, 2016-05-13 [InstanceEdit:8871278] Rothfels, Karen, 2016-05-13 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:8939808] Rothfels, Karen, 2016-09-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FCHo proteins bind nascent clathrin-coated pit
output	[Complex:8862276] PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:8870617] Antonescu, Costin N, 2016-05-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873437] R-HSA-8862280.4
summation	[Summation:8862256] Stabilization of the transient binding of AP-2 and clathrin ...
(hasEvent)	[Pathway:8856828] Clathrin-mediated endocytosis [Homo sapiens]
(precedingEvent)	[Reaction:8856808] Recruitment of AP-2 complex and clathrin [Homo sapiens]
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No pathways have been reviewed or authored by FCHo proteins bind nascent clathrin-coated pit (8862280)