Query author contributions in Reactome
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Details on Person Transmembrane protease serine 6 (Matriptase-2, TMPRSS6) regu...
| Class:Id | Summation:8862110 |
|---|---|
| _displayName | Transmembrane protease serine 6 (Matriptase-2, TMPRSS6) regu... |
| _timestamp | 2016-02-25 12:00:08 |
| created | [InstanceEdit:8862123] Jupe, Steve, 2016-02-25 |
| literatureReference | [LiteratureReference:8862119] The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin [LiteratureReference:8862109] Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis [LiteratureReference:8862118] Identification of TMPRSS6 cleavage sites of hemojuvelin |
| text | Transmembrane protease serine 6 (Matriptase-2, TMPRSS6) regulates hepcidin expression by cleaving hemojuvelin (HFE2), a bone morphogenetic protein (BMP) coreceptor (Silvestri et al. 2008, Rausa et al. 2015). Mutations in the TMPRSS6 gene are associated with severe iron-refractory iron deficiency anemia resulting from an overexpression of hepcidin, the key regulator of iron homeostasis (Ramsay et al. 2009). |
| (summation) | [Reaction:8862107] TMPRSS6 cleaves HFE2 [Homo sapiens] |
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No pathways have been reviewed or authored by Transmembrane protease serine 6 (Matriptase-2, TMPRSS6) regu... (8862110)
