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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person Diagram of Antimicrobial peptides

Class:IdPathwayDiagram:8861801
_displayNameDiagram of Antimicrobial peptides
_timestamp2025-06-23 08:29:54
created[InstanceEdit:8861800] Shamovsky, Veronica, 2016-02-20
height1702
modified[InstanceEdit:8933470] Shamovsky, Veronica, 2016-08-04
[InstanceEdit:8944205] Shamovsky, Veronica, 2016-11-03
[InstanceEdit:8948031] Shamovsky, Veronica, 2016-11-08
[InstanceEdit:9034692] Shamovsky, Veronica, 2018-01-10
[InstanceEdit:9034693] Shamovsky, Veronica, 2018-01-10
[InstanceEdit:9699057] Matthews, Lisa, 2020-09-09
[InstanceEdit:9853047] Shamovsky, Veronica, 2023-11-09
[InstanceEdit:9958558] Stephan, Ralf, 2025-06-23
representedPathway[Pathway:6803157] Antimicrobial peptides [Homo sapiens]
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id="300" reactomeId="1470067" position="384 1376" bounds="366 1361 36 30" textPosition="372 1365" /> <org.gk.render.RenderableProtein id="301" reactomeId="437103" position="308 1240" bounds="277 1229 63 22" textPosition="279 1229"> <Properties> <displayName>SLC11A1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="310" reactomeId="6803540" position="379 1489" bounds="354 1474 50 30" textPosition="360 1478"> <Properties> <displayName>Cu1+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="311" reactomeId="29372" position="413 1576" bounds="400 1561 27 30" textPosition="404 1565"> <Properties> <displayName>Pi</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="313" reactomeId="6803541" position="320 1446" bounds="269 1435 103 22" textPosition="273 1435" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ATP7A:PDZD11</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="341" reactomeId="8858201" position="708 1410" bounds="659 1392 98 36" textPosition="663 1392" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>GNLY:bacterial anionic lipids</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntity id="342" reactomeId="8879165" position="2072 282" bounds="2007 264 130 36" textPosition="2011 271" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>Microbial cell surface</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableComplex id="343" reactomeId="8879163" position="1892 288" bounds="1827 263 131 50" textPosition="1831 277" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CAMP(134-170):microbial cell surface</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="344" reactomeId="8931784" position="171 556" bounds="106 524 131 64" textPosition="106 552" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true" /> <org.gk.render.RenderableComplex id="345" reactomeId="6803066" position="1536 902" bounds="1492 884 89 36" textPosition="1497 884" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>DCD:anionic phospholipid</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="346" reactomeId="6798557" position="1853 1099" bounds="1793 1081 121 36" textPosition="1798 1081" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>S100A7, S100A7A:Ca2+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="348" reactomeId="113592" position="230 1530" bounds="210 1515 40 30" textPosition="214 1519"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="349" reactomeId="3697875" position="226 1484" bounds="183 1473 87 22" textPosition="185 1473" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ATOX1:Cu1+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="350" reactomeId="29356" position="248 1565" bounds="227 1550 43 30" textPosition="232 1554" /> <org.gk.render.RenderableChemical id="351" reactomeId="29370" position="427 1534" bounds="407 1519 41 30" textPosition="412 1523"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="352" reactomeId="3697884" position="455 1483" bounds="430 1472 50 22" textPosition="430 1472"> <Properties> <displayName>ATOX1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="383" reactomeId="8931784" position="731 1322" bounds="666 1290 131 64" textPosition="666 1318" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>Anionic phospholipids:microbial cell surface</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="386" reactomeId="158417" position="589 184" bounds="565 169 49 30" textPosition="570 173"> <Properties> <displayName>Zn2+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.ProcessNode id="391" reactomeId="1461973" position="234 112" bounds="159 82 150 61" textPosition="198 97"> <Properties> <displayName>Defensins</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableProtein id="405" reactomeId="6806202" position="90 394" bounds="75 383 31 22" textPosition="76 383"> <Properties> <displayName>LYZ</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="406" reactomeId="8862293" position="146 287" bounds="116 276 61 22" textPosition="119 276" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LYZ:PGN</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="412" reactomeId="109276" position="163 221" bounds="142 206 43 30" textPosition="147 210"> <Properties> <displayName>H2O</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="413" reactomeId="6788991" position="357 285" bounds="303 274 108 22" textPosition="310 274" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>MurNAc:Peptide</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="414" reactomeId="6788982" position="243 285" bounds="200 270 87 30" textPosition="208 274" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>betaGlcNAc</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="425" reactomeId="1602363" position="1999 956" bounds="1948 945 102 22" textPosition="1953 945" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PLA2G2A:Ca2+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="426" reactomeId="8862769" position="2160 905" bounds="2112 887 96 36" textPosition="2118 887" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PLA2G2A:phospholipids</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="456" reactomeId="8933468" position="661 144" bounds="610 133 102 22" textPosition="615 133" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PGLYRP2 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="457" reactomeId="8944198" position="1660 1200" bounds="1604 1182 113 36" textPosition="1610 1182" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>S100A8:S100A9:Ca2+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="458" reactomeId="8944189" position="1931 1160" bounds="1875 1142 113 36" textPosition="1881 1142" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>S100A8:S100A9:Ca2+:Zn2+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="460" reactomeId="8948028" position="2491 756" bounds="2430 731 123 50" textPosition="2439 731" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RNASEs 3,6,7,(8):anionic phospholipids</displayName> </Properties> </org.gk.render.RenderableComplex> </Nodes> <Edges> <org.gk.render.RenderableReaction id="8" reactomeId="1222685" points="1991 238, 1963 249, 1937 260" position="1963 249" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="9" points="1969 203" /> <Input id="342" points="2038 261" /> </Inputs> <Outputs> <Output id="343" /> </Outputs> <Properties> <displayName>Cathelicidin LL-37 binds to bacterial cell wall</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="11" reactomeId="6801687" points="1808 207, 1829 186, 1908 187" position="1829 186" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="12" /> </Inputs> <Outputs> <Output id="9" /> </Outputs> <Catalysts> <Catalyst id="13" points="1829 157" /> </Catalysts> <Properties> <displayName>PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14" reactomeId="6802999" points="1326 1038, 1352 1037, 1368 1037" position="1352 1037" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="15" /> </Inputs> <Outputs> <Output id="16" points="1399 1063" /> <Output id="17" points="1378 1015" /> </Outputs> <Properties> <displayName>DCD is processed into DCD(63-110)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="18" reactomeId="6803060" points="1431 1001, 1475 1001, 1522 971" position="1475 1001" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="17" /> </Inputs> <Outputs> <Output id="19" /> </Outputs> <Catalysts> <Catalyst id="20" points="1486 1017" /> </Catalysts> <Properties> <displayName>DCD(63-110) is processed to DCD(63-109)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="25" reactomeId="6803047" points="1398 925, 1426 923, 1489 910" position="1426 923" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="344" points="240 575" /> <Input id="27" points="1328 941" /> </Inputs> <Outputs> <Output id="345" /> </Outputs> <Properties> <displayName>DCD peptide binds bacterial membrane phospholipids</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="28" points="1490 957, 1347 957" position="1418 957" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="19" /> </Inputs> <Outputs> <Output id="27" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="29" points="1355 987, 1317 975" position="1336 981" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="17" /> </Inputs> <Outputs> <Output id="27" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="35" reactomeId="6803104" points="1782 944, 1804 944, 1838 929" position="1804 944" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="36" stoichiometry="12" points="1724 985" /> <Input id="37" stoichiometry="6" points="1750 933" /> </Inputs> <Outputs> <Output id="39" /> </Outputs> <Properties> <displayName>DCD forms oligomeric complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="44" reactomeId="6789072" points="772 1530, 811 1530, 850 1543" position="811 1530" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="45" points="733 1595" /> <Input id="46" points="733 1530" /> </Inputs> <Outputs> <Output id="47" /> </Outputs> <Activators> <Activator id="48" points="618 1454" /> </Activators> <Properties> <displayName>PGLYRP1 binds bacterial peptidoglycan</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="50" reactomeId="6799977" points="912 238, 937 237, 968 237" position="937 237" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="51" points="867 273" /> <Input id="52" points="865 238" /> </Inputs> <Outputs> <Output id="456" points="715 152, 1027 202" /> <Output id="53" points="978 272" /> <Output id="55" points="1053 261" /> </Outputs> <Catalysts> <Catalyst id="456" points="702 158, 931 216" /> </Catalysts> <Activators> <Activator id="386" points="617 187, 918 225" /> </Activators> <Properties> <displayName>PGLYRP2 hydrolyzes bacterial peptidoglycan</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="60" reactomeId="6799981" points="764 263, 795 263, 816 273" position="795 263" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="456" points="670 158" /> <Input id="61" points="223 444, 712 320" /> </Inputs> <Outputs> <Output id="51" /> </Outputs> <Properties> <displayName>PGLYRP2 binds bacterial peptidoglycan</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="62" reactomeId="6799959" points="498 262, 518 262, 552 268" position="518 262" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="63" points="478 247" /> <Input id="61" points="223 424" /> </Inputs> <Outputs> <Output id="64" /> </Outputs> <Activators> <Activator id="386" points="577 202, 537 253" /> </Activators> <Properties> <displayName>PGLYRP3,4 binds bacterial peptidoglycan</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="65" reactomeId="6801766" points="1081 101, 1135 101, 1157 101" position="1135 101" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="66" /> </Inputs> <Outputs> <Output id="67" points="1176 140" /> <Output id="68" points="1203 88" /> </Outputs> <Catalysts> <Catalyst id="69" points="1131 66" /> </Catalysts> <Properties> <displayName>Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="78" reactomeId="6801808" points="1226 262, 1246 261, 1286 267" position="1246 261" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="67" points="1191 188" /> <Input id="61" points="223 451, 1181 313" /> </Inputs> <Outputs> <Output id="79" /> </Outputs> <Properties> <displayName>REG3A,REG3G binds bacterial peptidoglycan</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="88" reactomeId="6801776" points="1441 241, 1477 242, 1494 262" position="1477 242" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="89" points="1386 177" /> <Input id="344" points="240 543, 1416 324" /> </Inputs> <Outputs> <Output id="91" /> </Outputs> <Properties> <displayName>REG3A binds bacterial phospholipids</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="90" points="1323 163, 1246 163" position="1284 163" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="89" /> </Inputs> <Outputs> <Output id="67" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="92" reactomeId="6801762" points="1571 273, 1635 252, 1669 263" position="1635 252" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="91" stoichiometry="6" /> </Inputs> <Outputs> <Output id="93" /> </Outputs> <Inhibitors> <Inhibitor id="94" points="1622 283, 1634 274" /> </Inhibitors> <Properties> <displayName>REG3A oligomerize to form a pore complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="99" reactomeId="6804527" points="2563 917, 2563 940, 2435 911" position="2563 940" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="100" points="2532 905" /> <Input id="101" points="2608 900" /> </Inputs> <Outputs> <Output id="102" /> </Outputs> <Properties> <displayName>INTL1 binds bacterial glycans</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="115" reactomeId="6803063" points="2623 704, 2624 744, 2566 791" position="2624 744" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="116" points="2546 659" /> <Input id="117" points="2680 635" /> </Inputs> <Outputs> <Output id="118" /> </Outputs> <Properties> <displayName>RNASEs bind bacterial LPS, PGN</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="119" reactomeId="6806732" points="552 938, 583 937, 614 911" position="583 937" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="344" points="202 591" /> <Input id="120" points="528 947" /> </Inputs> <Outputs> <Output id="121" /> </Outputs> <Properties> <displayName>GNLY binds the bacterial cell surface</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="124" reactomeId="6807565" points="505 969, 506 1107, 507 1200" position="506 1107" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="120" /> </Inputs> <Outputs> <Output id="125" /> </Outputs> <Properties> <displayName>GNLY is transferred to the phagosome</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="130" reactomeId="6807578" points="646 1341, 645 1376, 674 1389" position="645 1376" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="125" points="519 1228" /> <Input id="383" points="663 1336" /> </Inputs> <Outputs> <Output id="341" /> </Outputs> <Properties> <displayName>GNLY binds the bacterial cell surface in the phagosome</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="131" reactomeId="6807144" points="823 932, 851 931, 872 917" position="851 931" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="344" points="226 591" /> <Input id="132" points="791 967" /> </Inputs> <Outputs> <Output id="133" /> </Outputs> <Properties> <displayName>HTN1,HTN3 or HTN5 binds the bacterial anionic surface</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="134" reactomeId="6807581" points="1099 953, 1129 953, 1152 915" position="1129 953" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="135" points="1064 962" /> <Input id="137" points="1044 913" /> </Inputs> <Outputs> <Output id="138" /> </Outputs> <Properties> <displayName>HTN5, (HTN1, HTN3) binds fungal SSA1/SSA2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="136" points="968 980, 823 983" position="895 981" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="135" /> </Inputs> <Outputs> <Output id="132" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="178" reactomeId="6807585" points="2561 423, 2562 446, 2536 473" position="2562 446" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="179" points="2590 373" /> <Input id="180" points="2546 409" /> </Inputs> <Outputs> <Output id="182" /> </Outputs> <Properties> <displayName>BPI binds LPS on the bacterial surface</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="183" reactomeId="6808566" points="120 933, 156 933, 184 918" position="156 933" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="344" points="166 591" /> <Input id="184" points="92 950" /> </Inputs> <Outputs> <Output id="185" /> </Outputs> <Properties> <displayName>CHGA-derived peptide binds the bacterial cell surface</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="190" reactomeId="6810724" points="2580 420, 2583 459, 2545 521" position="2583 459" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="191" points="2631 376" /> <Input id="180" points="2555 402" /> </Inputs> <Outputs> <Output id="192" /> </Outputs> <Properties> <displayName>PI3 binds the bacterial surface</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="193" reactomeId="6809521" points="2177 261, 2208 261, 2241 277" position="2208 261" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="194" points="2176 243" /> <Input id="342" points="2140 269" /> </Inputs> <Outputs> <Output id="196" /> </Outputs> <Properties> <displayName>BPIF binds bacteria</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="198" reactomeId="6813626" points="316 922, 343 921, 375 910" position="343 921" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="344" points="183 591" /> <Input id="199" points="284 951" /> </Inputs> <Outputs> <Output id="200" /> </Outputs> <Properties> <displayName>LEAP2 binds bacteria</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="205" reactomeId="6810643" points="2126 135, 2219 136, 2538 292" position="2219 136" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="206" points="2059 108" /> <Input id="342" points="2078 261" /> </Inputs> <Outputs> <Output id="207" /> </Outputs> <Properties> <displayName>EPPIN protein complex binds bacteria</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="208" reactomeId="6813659" points="2120 180, 2214 180, 2381 280" position="2214 180" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="209" points="2070 160" /> <Input id="342" points="2080 261" /> </Inputs> <Outputs> <Output id="211" /> </Outputs> <Properties> <displayName>ELANE, CTSG or PRTN3 binds bacteria</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="210" points="1858 143, 1965 143" position="1911 143" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="13" /> </Inputs> <Outputs> <Output id="209" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="216" reactomeId="6798489" points="1911 1068, 1950 1069, 1988 1070" position="1950 1069" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="346" points="1886 1078" /> <Input id="36" stoichiometry="2" points="1733 1010" /> </Inputs> <Outputs> <Output id="219" /> </Outputs> <Properties> <displayName>S100A7 or S100A7A binds Zn2+</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="224" reactomeId="6798528" points="1785 1263, 1833 1262, 1880 1262" position="1833 1262" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="227" stoichiometry="2" points="1735 1305" /> <Input id="226" stoichiometry="2" points="1736 1264" /> <Input id="457" points="1695 1221" /> </Inputs> <Outputs> <Output id="228" /> </Outputs> <Properties> <displayName>S100A8:S100A9 binds Mn2+</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="229" reactomeId="6798474" points="1777 1160, 1826 1159, 1872 1159" position="1826 1159" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="457" points="1712 1179" /> <Input id="36" stoichiometry="4" points="1711 1021" /> </Inputs> <Outputs> <Output id="458" /> </Outputs> <Properties> <displayName>S100A8:S100A9 binds Zn2+</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="274" reactomeId="1222491" points="909 1218, 937 1218, 959 1218" position="937 1218" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="275" stoichiometry="2" points="879 1249" /> <Input id="276" points="871 1194" /> <Input id="277" stoichiometry="2" points="826 1215" /> </Inputs> <Outputs> <Output id="278" /> </Outputs> <Properties> <displayName>Lactoferrin scavenges iron ions</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="279" reactomeId="5229273" points="2266 1031, 2288 1032, 2327 1031" position="2288 1032" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="280" points="2247 1039" /> <Input id="281" points="2232 1018" /> </Inputs> <Outputs> <Output id="282" /> </Outputs> <Properties> <displayName>LCN2:2,5DHBA binds Fe3+</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="295" reactomeId="435171" points="324 1306, 324 1305, 324 1305" position="324 1305" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="297" points="273 1306" /> <Input id="300" points="371 1358" /> </Inputs> <Outputs> <Output id="296" points="300 1364" /> <Output id="298" points="389 1306" /> </Outputs> <Catalysts> <Catalyst id="301" points="310 1254" /> </Catalysts> <Properties> <displayName>NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="299" points="573 1427, 474 1338" position="523 1382" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="48" /> </Inputs> <Outputs> <Output id="298" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="306" reactomeId="6803545" points="293 1530, 321 1531, 366 1530" position="321 1531" lineWidth="1.0"> <Inputs> <Input id="348" points="253 1530" /> <Input id="349" points="242 1498" /> <Input id="350" points="267 1547" /> </Inputs> <Outputs> <Output id="351" points="404 1532" /> <Output id="311" points="397 1562" /> <Output id="310" points="374 1507" /> <Output id="352" points="434 1497" /> </Outputs> <Catalysts> <Catalyst id="313" points="316 1460, 300 1508" /> </Catalysts> <Properties> <displayName>ATP7A transports cytosolic Cu2+ to phagosomal lumen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="404" reactomeId="8862300" points="126 364, 126 339, 141 301" position="126 339" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="405" points="103 380" /> <Input id="61" points="146 421" /> </Inputs> <Outputs> <Output id="406" /> </Outputs> <Properties> <displayName>LYZ binds bacterial peptidoglycan</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="411" reactomeId="8862320" points="191 250, 225 250, 260 249" position="225 250" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="406" points="159 273" /> <Input id="412" points="177 239" /> </Inputs> <Outputs> <Output id="413" points="327 271" /> <Output id="414" points="250 267" /> </Outputs> <Catalysts> <Catalyst id="406" points="174 273, 208 263" /> </Catalysts> <Properties> <displayName>LYZ hydrolyzes peptidoglycans in the bacterial cell wall</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="424" reactomeId="8862771" points="2048 916, 2080 917, 2109 912" position="2080 917" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="344" points="240 565, 1966 830" /> <Input id="425" points="2012 942" /> </Inputs> <Outputs> <Output id="426" /> </Outputs> <Properties> <displayName>PLA2G2A binds bacterial phospholipids</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="459" reactomeId="8948027" points="2593 696, 2595 726, 2556 738" position="2595 726" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="117" points="2672 635" /> <Input id="344" points="240 559" /> </Inputs> <Outputs> <Output id="460" /> </Outputs> <Properties> <displayName>RNASEs bind bacterial phospholipids</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Antimicrobial peptides (8861801)
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