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Details on Person BMP2, BMP4 and BMP6 are endogenous ligands for Hemojuvelin (...

Class:IdSummation:8858633
_displayNameBMP2, BMP4 and BMP6 are endogenous ligands for Hemojuvelin (...
_timestamp2017-01-25 14:07:51
created[InstanceEdit:8858659] Jupe, Steve, 2016-02-19
literatureReference[LiteratureReference:8858598] Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin
[LiteratureReference:8858625] Homocysteine upregulates hepcidin expression through BMP6/SMAD signaling pathway in hepatocytes
[LiteratureReference:8957363] BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
[LiteratureReference:8957370] Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
[LiteratureReference:8957378] Conditional disruption of mouse HFE2 gene: maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin
modified[InstanceEdit:8861846] Jupe, Steve, 2016-02-22
[InstanceEdit:8957374] Jupe, Steve, 2017-01-25
[InstanceEdit:8957376] Jupe, Steve, 2017-01-25
textBMP2, BMP4 and BMP6 are endogenous ligands for Hemojuvelin (HFE2), a coreceptor for bone morphogenetic protein (BMP) signaling that regulates hepcidin expression and iron metabolism. In vitro, HFE2 selectively uses the BMP type II receptors ACVR2A and BMPR2, but not ACVR2B. HFE2 enhances utilization of ACVR2A by BMP2 and BMP4. ACVR2A is the predominant BMP type II receptor expressed in human liver. While HFE2 can use all 3 BMP type I receptors (ACVR1, BMPR1A, and BMPR1B) in vitro, only ACVR1 and BMPR1A are detected in human liver. Mutations of the HFE2 gene are linked to juvenile hemochromatosis, a severe hereditary iron overload disease caused by chronic hyperabsorption of dietary iron (Gkouvatsos et al. 2011).
(summation)[Reaction:8858553] BMP2,BMP4,BMP6 bind HFE2 [Homo sapiens]
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